Patents by Inventor Madhu S. Malo

Madhu S. Malo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VITRO DEVICE TO MEASURE STOOL ALKALINE PHOSPHATEASE
    Publication number: 20230097960
    Abstract: This invention describes a de novo in vitro device to measure STAP. Measurement of stool alkaline phosphatase (STAP) will be pivotal in determining the physiological as well as pharmacological effects of intestinal alkaline phosphatase (IAP), the major component of STAP. The device is described for measuring phosphatase concentration in stool. The device (chromogenic STAP Test) allows persistent contact of a stool sample for a specific period of time (e.g., 30 min) with a piece of chromatography paper (strip) impregnated with a STAP substrate (p-nitrophenyl phosphate, p-NPP), and then the developed color (yellow) is compared with standards thus providing the STAP concentration. For a permanent record, the developed color along with standards is photographed.
    Type: Application
    Filed: September 29, 2021
    Publication date: March 30, 2023
    Inventor: MADHU S. MALO
  • Diagnosis and treatment of incipient diabetes
    Patent number: 10781470
    Abstract: A method is described for predicting incipient diabetes, metabolic disorders or the metabolic syndrome by developing a personal temporal Phosphatase profile, which is generated by measuring phosphatase concentration in stool at a single time-point or multiple time-points. The phosphatase profile further can be used for diagnosing and determining prognosis of other incipient or overt diseases, such as the metabolic syndrome, coronary heart disease, nonalcoholic fatty liver disease, cancers, other chronic or acute diseases or infectious diseases. Also described is a specific dose of phosphatase for therapeutic use in incipient diabetes and other incipient or overt diseases.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: September 22, 2020
    Inventor: Madhu S. Malo
  • Methods of Modulating Gastrointestinal Tract Flora Levels with Alkaline Phosphatase
    Publication number: 20170252327
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to modulate gastrointestinal tract flora levels in subject.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 7, 2017
    Inventors: Richard A. Hodin, Madhu S. Malo
  • DIAGNOSIS AND TREATMENT OF INCIPIENT DIABETES
    Publication number: 20160201110
    Abstract: A method is described for predicting incipient diabetes, metabolic disorders or the metabolic syndrome by developing a personal temporal Phosphatase profile, which is generated by measuring phosphatase concentration in stool at a single time-point or multiple time-points. The phosphatase profile further can be used for diagnosing and determining prognosis of other incipient or overt diseases, such as the metabolic syndrome, coronary heart disease, nonalcoholic fatty liver disease, cancers, other chronic or acute diseases or infectious diseases. Also described is a specific dose of phosphatase for therapeutic use in incipient diabetes and other incipient or overt diseases.
    Type: Application
    Filed: November 17, 2015
    Publication date: July 14, 2016
    Inventor: Madhu S. Malo
  • Methods of reducing or inhibiting toxic effects associated with a bacterial infection using alkaline phosphatase
    Patent number: 8932587
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to reduce or inhibit toxic effects associated with a bacterial infection in a subject.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: January 13, 2015
    Assignee: The General Hospital Corporation
    Inventors: Richard A. Hodin, Madhu S. Malo
  • Methods of Reducing or Inhibiting Toxic Effects Associated with a Bacterial Infection Using Alkaline Phosphatase
    Publication number: 20130022591
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to reduce or inhibit toxic effects associated with a bacterial infection in a subject.
    Type: Application
    Filed: February 11, 2011
    Publication date: January 24, 2013
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Richard A. Hodin, Madhu S. Malo
  • Methods of Modulating Gastrointestinal Tract Flora Levels with Alkaline Phosphatase
    Publication number: 20110206654
    Abstract: This invention relates generally to a therapeutic use of alkaline phosphatase to modulate gastrointestinal tract flora levels in subject.
    Type: Application
    Filed: August 27, 2009
    Publication date: August 25, 2011
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Richard A. Hodin, Madhu S. Malo