Patents by Inventor Madhusudhan Reddy BOBBILI

Madhusudhan Reddy BOBBILI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Target-specific extracellular vesicles
    Patent number: 12146238
    Abstract: Provided herein is a method of producing a protein comprising a target-specific extravesicular domain (TED) of an extracellular vesicle (EV) surface protein comprising modifying a polynucleotide comprising a nucleotide sequence encoding the extravesicular domain (ED) of an EV surface protein by a mutagenesis method within at least one modified region within the ED amino acid sequence with a length of 3-20 contiguous amino acids flanked by regions of the wild-type ED sequence at its N-terminus and C-terminus, to incorporate a target binding site within the ED, thereby producing a repertoire of polynucleotides encoding a variety of TEDs, each comprising a different target binding site, and selecting a TED specifically recognizing a predetermined target, and producing the protein comprising the selected TED.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: November 19, 2024
    Assignee: EVERCYTE GMBH
    Inventors: Gordana Wozniak-Knopp, Stefan Vogt, Gerhard Stadlmayr, Florian Rueker, Johannes Grillari, Madhusudhan Reddy Bobbili
  • TARGET-SPECIFIC EXTRACELLULAR VESICLES
    Publication number: 20210395725
    Abstract: Provided herein is a method of producing a protein comprising a target-specific extravesicular domain (TED) of an extracellular vesicle (EV) surface protein comprising modifying a polynucleotide comprising a nucleotide sequence encoding the extravesicular domain (ED) of an EV surface protein by a mutagenesis method within at least one modified region within the ED amino acid sequence with a length of 3-20 contiguous amino acids flanked by regions of the wild-type ED sequence at its N-terminus and C-terminus, to incorporate a target binding site within the ED, thereby producing a repertoire of polynucleotides encoding a variety of TEDs, each comprising a different target binding site, and selecting a TED specifically recognizing a predetermined target, and producing the protein comprising the selected TED.
    Type: Application
    Filed: August 14, 2019
    Publication date: December 23, 2021
    Inventors: Gordana WOZNIAK-KNOPP, Stefan VOGT, Gerhard STADLMAYR, Florian RUEKER, Johannes GRILLARI, Madhusudhan Reddy BOBBILI