Abstract: The invention relates to the field of immunotherapy and vaccine treatment of diseased cells via enhancing the immune response to the diseased cells. In the context of the present invention this is done by engineering neo-antigens in cells via oligonucleotide mediated production of aberrant RNA transcripts which, when transcribed in the cell, result in the generation or increased expression of aberrant polypeptides. Extracellular display of these polypeptides, of peptide fragments derived provides antigen epitopes (neoantigen) for detection by the immune system.

Abstract: The invention relates to the field of therapeutic oligonucleotide analytics, and provides methods for primer based parallel sequencing of therapeutic oligonucleotides which provide sequence based quality information which may be used in conjunction with or in place of present chromatography or mass spectroscopic methods, and may be used, for example, in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.

Abstract: The invention relates to the field of therapeutic oligonucleotide analytics and discovery, and provides methods for primer based parallel sequencing of modified oligonucleotides which provide sequence based quality information which may be used in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.

Abstract: The invention relates to the field of therapeutic oligonucleotide analytics and discovery, and provides methods for primer based parallel sequencing of modified oligonucleotides which provide sequence based quality information which may be used in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.

Abstract: Various embodiments provide systems and methods enabling a user to receive feedback regarding a computer-implemented design of an architectural structure as the user is designing or otherwise modifying the computer-implemented design using a computer-aided design (CAD) software tool. The feedback (hereafter also referred to as “design feedback”) may provide the user with useful analysis information regarding the architectural structure's predicted characteristics (e.g., operational performance, resource consumption, cost, etc.) based on the current state of the computer-implemented design. In particular, daylighting analyses pertinent to the computer-implemented design of the architectural structure can be visually displayed to the user in real or near-real-time.

Abstract: Various embodiments provide systems and methods enabling a user to receive feedback regarding a computer-implemented design of an architectural structure as the user is designing or otherwise modifying the computer-implemented design using a computer-aided design (CAD) software tool. The feedback (hereafter also referred to as “design feedback”) may provide the user with useful analysis information regarding the architectural structure's predicted characteristics (e.g., operational performance, resource consumption, cost, etc.) based on the current state of the computer-implemented design. In particular, daylighting analyses pertinent to the computer-implemented design of the architectural structure can be visually displayed to the user in real or near-real-time.

Abstract: Various embodiments provide systems and methods that can be configured to analyze implementing one or more conservation measures (CMs) to an architectural structure, which can include proposing one or more sequences for implementing the conservation measures. Some embodiments may assist in identifying which conservation measures to implement, determining benefits of implementing selected conservation measures, or planning implementation of selected conservation measures. Those conservation measures selected for implementation may be part of a retrofit plan intended for an architectural structure to improve utility usage by that architectural structure. Accordingly, certain embodiments can help in assessing risks of a retrofit plan, or determining the time, scope, budget, or quality of the retrofit plan.