Patents by Inventor Mads Kearn

Mads Kearn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered enzymatically active bacteriophages and methods of uses thereof
    Patent number: 8182804
    Abstract: The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: May 22, 2012
    Assignees: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: James J Collins, Hideki Kobayashi, Mads Kearn, Michihiro Araki, Ari Friedland, Timothy Kuan-Ta Lu