Patents by Inventor Mae J. Rosok

Mae J. Rosok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibody compositions cross-reactive and cross-protective against P. aeruginosa serotypes
    Patent number: 5662905
    Abstract: Cell lines have been produced that secrete human monoclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included. Prior to filing of this patent application the continuous transformed human cell lines 1C1, 6D6 and 8H7 described herein were deposited in the American Type Culture Collection and given the designations CRL 8941, 9171, and 9258, respectively.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: September 2, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anthony W. Siadak, Mae J. Rosok
  • Method for inhibiting the viability of Pseudomonas aeruginosa with cross-reactive and cross-protective monoclonal antibodies
    Patent number: 5628996
    Abstract: Cell lines have been produced that secrete human monclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 13, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anthony W. Siadak, Mae J. Rosok
  • Monoclonal antibodies cross-reactive and cross-protective against human monoclonal antibodies against pseudomonas aeruginosa serotypes
    Patent number: 5627067
    Abstract: Cell lines have been produced that secrete human monclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.Prior to filing of this patent application the continuous transformed human cell lines 1C1, 6D6, and 8H7 described herein were deposited in the American Type Culture Collection and given the designations CRL 8941, 9171, and 9258, respectively.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 6, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anthony W. Siadak, Mae J. Rosok
  • Monoclonal antibodies cross-reactive and cross-protective against P. aeruginosa serotypes
    Patent number: 5378812
    Abstract: Cell lines have been produced that secrete human monclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.Prior to filing of this patent application the continuous transformed human cell lines 1C1, 6D6, and 8H7 described herein were deposited in the American Type Culture Collection and given the designations CRL 8941, 9171, and. 9258, respectively.
    Type: Grant
    Filed: May 24, 1993
    Date of Patent: January 3, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anthony W. Siadak, Mae J. Rosok
  • Monoclonal antibodies to pseudomonas aeruginosa flagella
    Patent number: 4834976
    Abstract: Cell lines have been produced that secrete monoclonal antibodies capable of binding to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included.Prior to filing this application, the continuous transformed cell lines PaF4 IVE8, FA6 IIG5, 20H11, and 21B8, described herein, were deposited in the America Type Culture Collection and given the designations HB9129, HB9130, CRL 9300, and CRL 9301, respectively.
    Type: Grant
    Filed: December 24, 1986
    Date of Patent: May 30, 1989
    Assignee: Genetic Systems Corporation
    Inventors: Mae J. Rosok, Mark E. Lostrom