Patents by Inventor Magdalena DORYWALSKA

Magdalena DORYWALSKA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-drug conjugates with high drug loading
    Patent number: 11602525
    Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: March 14, 2023
    Assignees: RINAT NEUROSCIENCE CORP., PFIZER INC.
    Inventors: Pavel Strop, Katherine Anne Delaria, Magdalena Dorywalska, Davide Luciano Foletti, Russell George Dushin, David Louis Shelton, Arvind Rajpal
  • ANTIBODY-DRUG CONJUGATES WITH HIGH DRUG LOADING
    Publication number: 20170043033
    Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 16, 2017
    Applicants: RINAT NEUROSCIENCE CORP., PFIZER INC.
    Inventors: Pavel STROP, Katherine Anne DELARIA, Magdalena DORYWALSKA, Davide Luciano FOLETTI, Russell George DUSHIN, David Louis SHELTON, Arvind RAJPAL