Abstract: A substituted chroman compound includes R1a and R1b as substituents selected from hydrogen and phenyl optionally substituted with 1-3 substituents. R2a and R2b are hydrogen atoms. R3a and R3b are C1-C4 alkyls, or represent an oxo group, or are C5-C8 alkylene substituents. R3a and R3b with their attached carbon atom form a ring. Nitrogen atoms replace two non-adjacent carbon atoms in the main chain to the C5-8 alkylene, which is optionally substituted by a thioxo group. n is the number of the substituents Rz. z is the sequence number of the substituent Rz. (Rz) is a substituent on the benzene ring attached to a non-nodal carbon atom selected from hydroxyl, halogen, C2-C6 alkenyl, C1-C4 alkoxy, C1-4 alkanoyloxy, heterocyclic C4-C7 alkyloxy having an oxygen atom in the ring and optionally substituted with 1-3 substituents. The compound is used as a tautomer, enantiomer, diastereomer, mixture of enantiomers and/or mixture of diastereomers.

Abstract: The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumor cells.

Abstract: The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumour cells.