Patents by Inventor Magdiel Pérez Cruz

Magdiel Pérez Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF A PERIOSTIN ANTIBODY FOR TREATING INFLAMMATION, FIBROSIS AND LUNG DISEASES
    Publication number: 20240141026
    Abstract: The present invention is based on the surprising finding that the MPC5B4 anti-periostin monoclonal antibody can effectively prevent and treat inflammation, fibrosis and worsening of pulmonary inflammation and respiratory diseases in various animal models. The MPC5B4 anti-periostin monoclonal antibody recognizes specifically the peptide sequence of SEQ ID NO:1, corresponding to the amino acid sequence 136-151 located within the fasciclin (FAS)1-1 domain of the periostin protein (POSTN), inhibiting its binding to the ?v?3 integrin.
    Type: Application
    Filed: March 4, 2022
    Publication date: May 2, 2024
    Inventors: Magdiel PEREZ-CRUZ, Bernhard RYFFEL
  • BLOCKADE OF RGMb FOR TREATING INFLAMMATORY BOWEL DISEASE AND COLITIS
    Publication number: 20220267428
    Abstract: RGMb antagonists reduce undesirable immune responses associated with autoimmune conditions, including inflammatory bowel diseases such as colitis.
    Type: Application
    Filed: October 10, 2019
    Publication date: August 25, 2022
    Inventors: Everett Hurteau Meyer, Magdiel Perez Cruz
  • Systemic targeting of inflammatory sites and enhanced immunomodulatory function by introducing the chimeric antigen receptor (CAR) into mesenchymal stem cells for inflammatory and autoimmune diseases
    Patent number: 11246890
    Abstract: Mesenchymal stromal cells are engineered to express a chimeric antigen receptor (CAR), that specifically binds a marker of activated myeloid cells, including without limitation folate receptor beta; and are administered to an individual for treatment of inflammation at sites characterized by the presence of activated myeloid cells.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: February 15, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tzuhua Dennis Lin, Stuart B. Goodman, Sai-Wen Tang, Everett Hurteau Meyer, Magdiel Pérez Cruz
  • Blockade of RGMB for reducing transplantation-associated inflammation leading to loss of function of a transplanted organ in a graft recipient
    Patent number: 10669335
    Abstract: RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: June 2, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Everett Hurteau Meyer, Rosemarie H. Dekruyff, Panagiota Iliopoulou, Yuchiao Hsu, Magdiel Pérez Cruz
  • TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY ANTAGONISM OF THE IL-20R
    Publication number: 20190330330
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acme exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of IL-20 cytokines.
    Type: Application
    Filed: July 10, 2019
    Publication date: October 31, 2019
    Inventors: Philippe GOSSET, Muriel PICHAVANT, Magdiel PEREZ-CRUZ, Bachirou KONE
  • REGULATORY T CELLS TARGETED WITH CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20190307795
    Abstract: Regulatory T cells (Treg) are engineered to express a chimeric antigen receptor (CAR), that specifically binds folate receptor beta; and are administered to an individual for treatment of inflammation at sites characterized by the presence of activated myeloid cells. Also provided are methods for utilized engineered T regulatory cells to enhance hematopoietic cell transplantation.
    Type: Application
    Filed: January 24, 2019
    Publication date: October 10, 2019
    Inventors: Sai-Wen Tang, Panagiota Iliopoulou, Magdiel Perez Cruz, Everett Hurteau Meyer
  • SYSTEMIC TARGETING OF INFLAMMATORY SITES AND ENHANCED IMMUNOMODULATORY FUNCTION BY INTRODUCING THE CHIMERIC ANTIGEN RECEPTOR (CAR) INTO MESENCHYMAL STEM CELLS FOR INFLAMMATORY AND AUTOIMMUNE DISEASES
    Publication number: 20190298774
    Abstract: Mesenchymal stromal cells are engineered to express a chimeric antigen receptor (CAR), that specifically binds a marker of activated myeloid cells, including without limitation folate receptor beta; and are administered to an individual for treatment of inflammation at sites characterized by the presence of activated myeloid cells.
    Type: Application
    Filed: April 1, 2019
    Publication date: October 3, 2019
    Inventors: Tzuhua Dennis Lin, Stuart B. Goodman, Sai-Wen Tang, Everett Hurteau Meyer, Magdiel Pérez Cruz
  • BLOCKADE OF RGMb FOR REDUCING TRANSPLANTATION-ASSOCIATED IMMUNE RESPONSES
    Publication number: 20190077861
    Abstract: RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.
    Type: Application
    Filed: September 5, 2018
    Publication date: March 14, 2019
    Inventors: Everett Hurteau Meyer, Rosemarie H. Dekruyff, Panagiota Iliopoulou, Yuchiao Hsu, Magdiel Pérez Cruz
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Publication number: 20180344807
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.
    Type: Application
    Filed: July 30, 2018
    Publication date: December 6, 2018
    Inventors: Philippe GOSSET, Muriel PICHAVANT, Jean-Claude SIRARD, Bachirou KONE, Magdiel PEREZ-CRUZ
  • Blockade of RGMb for reducing transplantation-associated immune responses
    Patent number: 10093734
    Abstract: RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: October 9, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Everett Hurteau Meyer, Rosemarie H. Dekruyff, Panagiota Iliopoulou, Yuchiao Hsu, Magdiel Perez Cruz
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Publication number: 20170354709
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.
    Type: Application
    Filed: December 23, 2015
    Publication date: December 14, 2017
    Inventors: Philippe GOSSET, Muriel PICHAVANT, Jean-Claude SIRARD, Bachirou KONE, Magdiel PEREZ-CRUZ
  • TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY ANTAGONISM OF THE IL-20R
    Publication number: 20170327572
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of IL-20 cytokines.
    Type: Application
    Filed: November 23, 2015
    Publication date: November 16, 2017
    Inventors: Philippe GOSSET, Muriel PICHAVANT, Magdiel PEREZ-CRUZ, Bachirou KONE
  • BLOCKADE OF RGMb FOR REDUCING TRANSPLANTATION-ASSOCIATED IMMUNE RESPONSES
    Publication number: 20170121404
    Abstract: RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.
    Type: Application
    Filed: November 3, 2016
    Publication date: May 4, 2017
    Inventors: Everett Hurteau Meyer, Rosemarie H. Dekruyff, Panagiota Iliopoulou, Yuchiao Hsu, Magdiel Perez Cruz