Patents by Inventor Magdolna G. Sebestyén

Magdolna G. Sebestyén has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for targeting hepatocytes
    Patent number: 7501394
    Abstract: We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: March 10, 2009
    Assignee: Roche Madison Inc.
    Inventors: Alexander V. Sokoloff, So Wong, Jon A. Wolff, Sean D. Monahan, James Ludtke, Lori Higgs, Darren H. Wakefield, Magdolna G. Sebestyén
  • Regulation of Transgene Expression by RNA Interference
    Publication number: 20090023670
    Abstract: Expression of transgenes delivered into a host organism cells can be regulated by RNA effector molecules delivered to or present in the host organism cells. Regulation can be mediated by delivery of RNA interference inducing molecules that target the transgene mRNA or by incorporating engineered RNA effector binding sites into the transgene. Temporary or long term regulation of expression can be achieved depending on the nature and dosing of RNA effector.
    Type: Application
    Filed: May 18, 2007
    Publication date: January 22, 2009
    Inventor: Magdolna G. Sebestyen
  • Compounds for targeting hepatocytes in vivo
    Patent number: 7071163
    Abstract: We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: July 4, 2006
    Assignee: Mirus Bio Corporation
    Inventors: Alexander V. Sokoloff, So Wong, Jon A. Wolff, Sean D. Monahan, James Ludtke, Lori Higgs, Darren Wakefield, Magdolna G. Sebestyén
  • Compounds for targeting hepatocytes in vivo
    Publication number: 20040029826
    Abstract: We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.
    Type: Application
    Filed: August 4, 2003
    Publication date: February 12, 2004
    Inventors: Alexander V. Sokoloff, So Wong, Jon A. Wolff, Sean D. Monahan, James Ludtke, Lori Higgs, Darren Wakefield, Magdolna G. Sebestyen
  • Targeting nucleic acids to a cellular nucleus
    Publication number: 20030032597
    Abstract: We disclose gene delivery systems that target exogenous nucleic acids to the nucleus of mammalian cells and are delivered to chromatin during cellular mitosis, remaining within the nucleus after mitosis.
    Type: Application
    Filed: July 22, 2002
    Publication date: February 13, 2003
    Inventor: Magdolna G. Sebestyen
  • Method for covalent attachment of compounds to genes
    Patent number: 6093701
    Abstract: The described invention relates to methods for covalently attaching a compound to a gene. The method provides for covalently attaching compounds to genes for enhancing the cellular transport of the genes to predetermined targets, while maintaining the gene's functionality.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: July 25, 2000
    Assignee: Mirus, Inc.
    Inventors: Jon A. Wolff, James E. Hagstrom, Magdolna G. Sebestyen, Vladimir Budker