Patents by Inventor Maged Henary

Maged Henary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250144250
    Abstract: The present application provides pH-sensitive fluorophores, pharmaceutical compositions comprising pH-sensitive fluorophores, and methods for imaging of cancerous tumors comprising administering to the subject an effective amount of a compound or a pharmaceutical composition, waiting a time sufficient to allow the compound to accumulate in the cancerous tumor to be imaged, and imaging the cancerous tumor with a fluorescence imaging technique. Further provided methods of treating cancer, comprising imaging a cancerous tumor in a subject; and surgically removing the cancerous tumor from the subject.
    Type: Application
    Filed: January 31, 2023
    Publication date: May 8, 2025
    Inventors: Hak Soo Choi, Satoshi Kashiwagi, Maged Henary
  • Publication number: 20250109104
    Abstract: The present invention is directed to squaraine fluorophores, methods of making squaraine fluorophores, and methods of using squaraine fluorophores. In some embodiments, squaraine fluorophores can be used as imaging agents, for example for imaging cancer. In some embodiments, the squaraine fluorophores can be used to guide surgical tumor resection.
    Type: Application
    Filed: February 8, 2023
    Publication date: April 3, 2025
    Inventors: Maged Henary, Hak Soo Choi, Satoshi Kashiwagi
  • Patent number: 11738095
    Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 29, 2023
    Assignee: Emory University
    Inventors: Leland W. K. Chung, Lucjan Strekowski, Chunmeng Shi, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu, Ruoxiang Wang, Haiyen E. Zhau
  • Publication number: 20230248832
    Abstract: The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.
    Type: Application
    Filed: March 17, 2023
    Publication date: August 10, 2023
    Inventors: Leland W.K. Chung, Xiaojian Yang, Jianjun Cheng, Rong Tong, Maged Henary
  • Patent number: 11572475
    Abstract: Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: February 7, 2023
    Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Maged Henary, W. David Wilson
  • Patent number: 10377901
    Abstract: Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 13, 2019
    Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Maged Henary, Gabor Patonay
  • Publication number: 20180327427
    Abstract: This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[S—CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 15, 2018
    Applicant: Lahjavida, LLC
    Inventors: James J. Krutak, Lyle Small, Maged Henary, Gabor Patonay
  • Patent number: 10030036
    Abstract: This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: July 24, 2018
    Assignee: Lahjavida, LLC
    Inventors: James J. Krutak, Lyle Small, Maged Henary, Gabor Patonay
  • Publication number: 20170354747
    Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
    Type: Application
    Filed: February 2, 2017
    Publication date: December 14, 2017
    Inventors: Leland W.K. Chung, Lucjan Strekowski, Chunmeng Shi, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu, Ruoxiang Wang, Haiyen E. Zhau
  • Publication number: 20170303817
    Abstract: Provided herein are articles that comprise a fluorophore (such as a near infrared (NIR) agent or a fluorescent protein) affixed to a surgical article. Methods of detecting the surgical article within the body cavity of a subject are also provided. In some aspects, the detection of a surgical article left within the body cavity of the subject can occur prior to closing the body cavity after a surgical procedure. Methods of making the surgical articles are also provided.
    Type: Application
    Filed: November 10, 2015
    Publication date: October 26, 2017
    Inventors: Maged Henary, Jordan L. Malray
  • Publication number: 20170233577
    Abstract: Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 17, 2017
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Maged Henary, Gabor Patonay
  • Publication number: 20160310604
    Abstract: The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.
    Type: Application
    Filed: January 26, 2016
    Publication date: October 27, 2016
    Inventors: Leland W.K. Chung, Xiaojian Yang, Jianjun Cheng, Rong Tong, Maged Henary
  • Publication number: 20150376209
    Abstract: This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.
    Type: Application
    Filed: May 12, 2010
    Publication date: December 31, 2015
    Inventors: JAMES J. KRUTAK, Lyle Small, Maged Henary, Gabor Patonay
  • Publication number: 20140142147
    Abstract: Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.
    Type: Application
    Filed: July 18, 2012
    Publication date: May 22, 2014
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Maged Henary, W. David Wilson
  • Publication number: 20130075675
    Abstract: A thermochromic leuco dye composition contains a leuco dye moiety including one or more tri-aryl substituted pyridines, a UVA developer moiety including at least one UVA developer selected from the group consisting of salicylic acid and derivatives thereof, and biphenyls and derivatives thereof, and a carrier selected from the group consisting of a fatty ester, fatty alcohol, fatty amide, and combinations thereof.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 28, 2013
    Applicant: CHROMATIC TECHNOLOGIES, INC.
    Inventors: James J. Krutak, Maged Henary, Timothy J. Owen, Chromatic Technologies, Inc.
  • Publication number: 20110262354
    Abstract: This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.
    Type: Application
    Filed: July 10, 2008
    Publication date: October 27, 2011
    Inventors: Leland W. K. Chung, Ruoxiang Wang, Haiyen E. Zhau, Lucjan Strekowski, Maged Henary, Gabor Patonay, James J. Krutak, Xiaojian Yang, Guodong Zhu