Patents by Inventor Maggie Lee

Maggie Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFICATIONS OF MAMMALIAN CELLS USING ARTIFICIAL MICRO-RNA TO ALTER THEIR PROPERTIES AND THE COMPOSITIONS OF THEIR PRODUCTS
    Publication number: 20240093196
    Abstract: The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.
    Type: Application
    Filed: November 29, 2023
    Publication date: March 21, 2024
    Inventors: Jeremy MINSHULL, Maggie LEE
  • DNA VECTORS AND ELEMENTS FOR SUSTAINED GENE EXPRESSION IN EUKARYOTIC CELLS
    Publication number: 20240052367
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel elements that further improve expression. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Application
    Filed: June 8, 2023
    Publication date: February 15, 2024
    Applicant: DNA TWOPOINTO INC.
    Inventors: Jeremy MINSHULL, Maggie LEE
  • Modifications of mammalian cells using artificial micro-RNA to alter their properties and the compositions of their products
    Patent number: 11845936
    Abstract: The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: December 19, 2023
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Maggie Lee
  • MODIFICATIONS OF MAMMALIAN CELLS USING ARTIFICIAL MICRO-RNA TO ALTER THEIR PROPERTIES AND THE COMPOSITIONS OF THEIR PRODUCTS
    Publication number: 20230313187
    Abstract: The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.
    Type: Application
    Filed: September 3, 2021
    Publication date: October 5, 2023
    Applicant: DNA TWOPOINTO INC.
    Inventors: Jeremy MINSHULL, Maggie LEE, Varsha SITARAMAN, Oren BESKE, Ferenc BOLDOG
  • MODIFICATION OF T CELLS
    Publication number: 20230302054
    Abstract: Modified immune cells are provided, the modified immune cells expressing a heterologous polynucleotide comprising a nucleotide sequence encoding a function (e.g., at least one of persistence, proliferation, or cytotoxicity) booster, e.g., an apoptosis inhibitor. In one aspect, the modified T cells further comprise a chimeric antigen receptor. Methods, kits, and components for making and using the modified immune cells are also provided.
    Type: Application
    Filed: March 20, 2023
    Publication date: September 28, 2023
    Applicants: DNA Twopointo, The General Hospital Corporation
    Inventors: Yifang Shui, Jeremy Minshull, Maggie Lee, Feng Shi
  • MODIFICATIONS OF MAMMALIAN CELLS USING ARTIFICIAL MICRO-RNA TO ALTER THEIR PROPERTIES AND THE COMPOSITIONS OF THEIR PRODUCTS
    Publication number: 20230295625
    Abstract: The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce- cultured mammalian cells for therapeutic of diagnostic purposes.
    Type: Application
    Filed: December 29, 2022
    Publication date: September 21, 2023
    Inventors: Jeremy MINSHULL, Ferenc BOLDOG, Varsha SITARAMAN, Maggie LEE
  • DNA vectors and elements for sustained gene expression in eukaryotic cells
    Patent number: 11713468
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel elements that further improve expression. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: August 1, 2023
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Maggie Lee
  • INTEGRATION OF NUCLEIC ACID CONSTRUCTS INTO EUKARYOTIC CELLS WITH A TRANSPOSASE FROM ORYZIAS
    Publication number: 20230103199
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell.
    Type: Application
    Filed: June 3, 2022
    Publication date: March 30, 2023
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • TRANSPOSITION OF NUCLEIC ACID CONSTRUCTS INTO EUKARYOTIC GENOMES WITH A TRANSPOSASE FROM AMYELOIS
    Publication number: 20220411816
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Application
    Filed: June 22, 2022
    Publication date: December 29, 2022
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • DNA VECTORS, TRANSPOSONS AND TRANSPOSASES FOR EUKARYOTIC GENOME MODIFICATION
    Publication number: 20220282260
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Application
    Filed: May 18, 2022
    Publication date: September 8, 2022
    Inventors: Jeremy Minshull, Mark Welch, Sridhar Govindrajan, Maggie Lee, Kate Caves, Jon Ness
  • Integration of nucleic acid constructs into eukaryotic cells with a transposase from oryzias
    Patent number: 11401521
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: August 2, 2022
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • Transposition of nucleic acid constructs into eukaryotic genomes with a transposase from amyelois
    Patent number: 11396662
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: July 26, 2022
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • TRANSPOSON-BASED MODIFICATIONS OF IMMUNE CELLS
    Publication number: 20220170044
    Abstract: The present invention provides methods and compositions for stable genetic modification of immune cells. The genetic modifications can be used to produce immune cells for therapeutic or diagnostic purposes.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 2, 2022
    Applicants: DNA Twopointo, Inc., The General Hospital Corporation
    Inventors: Mark Cobbold, Maggie Lee, Jeremy Minshull, Feng Shi, Yifang Shui
  • MODIFICATIONS OF MAMMALIAN CELLS USING ARTIFICIAL MICRO-RNA TO ALTER THEIR PROPERTIES AND THE COMPOSITIONS OF THEIR PRODUCTS
    Publication number: 20220112500
    Abstract: The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.
    Type: Application
    Filed: November 4, 2021
    Publication date: April 14, 2022
    Applicant: DNA TWOPOINTO INC.
    Inventors: JEREMY MINSHULL, FERENC BOLDOG, VARSHA SITARAMAN, MAGGIE LEE
  • Modifications of mammalian cells using artificial micro-RNA to alter their properties and the compositions of their products
    Patent number: 11162102
    Abstract: The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: November 2, 2021
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Maggie Lee, Varsha Sitaraman, Ferenc Boldog
  • TRANSPOSITION OF NUCLEIC ACID CONSTRUCTS INTO EUKARYOTIC GENOMES WITH A TRANSPOSASE FROM AMYELOIS
    Publication number: 20210324408
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Application
    Filed: June 4, 2021
    Publication date: October 21, 2021
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • INTEGRATION OF NUCLEIC ACID CONSTRUCTS INTO EUKARYOTIC CELLS WITH A TRANSPOSASE FROM ORYZIAS
    Publication number: 20210292773
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 23, 2021
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • TRANSPOSITION OF NUCLEIC ACIDS INTO EUKARYOTIC GENOMES WITH A TRANSPOSASE FROM HELIOTHIS
    Publication number: 20210292719
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 23, 2021
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • Transposition of nucleic acid constructs into eukaryotic genomes with a transposase from amyelois
    Patent number: 11060109
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: July 13, 2021
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee
  • Transposition of nucleic acids into eukaryotic genomes with a transposase from heliothis
    Patent number: 11060086
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: July 13, 2021
    Assignee: DNA TWOPOINTO INC.
    Inventors: Jeremy Minshull, Sridhar Govindarajan, Maggie Lee