Abstract: A time-reversal mirroring electromagnetic acoustic treatment system is disclosed where electro-magnetic signals are directed to a region of interest in or on a patient. The EM signals induce an internally sourced acoustic signal due to variations in conductivity of the target tissue. Acoustic data representative of the induced acoustic signal are collected and analyzed to develop a model of a measured conductivity topology representing the conductivity topology of the target tissue. Measured parameters associated with the measured conductivity topology and derived from the acoustic data can be used to generate a time-reversed mirror acoustic treatment signal that can be used to apply a therapeutic treatment to a target tissue within the region of interest.