Abstract: Provided is a system for modeling the conventional outflow tract, including: a porous scaffold with trabecular meshwork cells attached to one surface and microvascular endothelial cells co-cultured on an opposite surface transforming the microvascular endothelial cells into Schlemm's canal cell-like cells. Also provided is a method for using the system for screening by contacting the cells with a known or suspected medicament and measuring its effects on the system such as flow of a perfusate. Also provided is a method of making the system by fabricating the porous substrate as a micropatterned scaffold.

Abstract: The present invention relates to a camera and a method for assembling a camera. The camera comprises a sensor, a lens, and a housing. The method comprises: adjusting a position of at least one of the sensor and the lens such that the sensor is positioned at a predetermined angle in relation to an optical axis of the lens, and laser welding the at least one of the sensor and the lens in relation to the housing such that the sensor and the lens are fixed in relation to each other.

Abstract: The present invention relates to methods of manufacture and utility of an artificial trabecular meshwork [TM] that utilizes micro- and nanofabricated materials bioengineered to mimic the structure and function of native outflow system of the eye.

Abstract: A method for solvent-less adhesive bonding is provided comprising depositing thin, functional, polymeric films on one or more substrates and bonding the substrates to each other or to other substrates. Depositing the polymeric films, including, for example, chemically reactive polymers and thermoplastics with adhesive qualities, may be accomplished using an initiated chemical vapor deposition technique compatible with a variety of monomers, including monomers with chemically functional moieties such as amine and epoxy groups. The technique allows for deposition of polymeric films on a wide variety of substrates/devices and provides an alternative for other coating/deposition methods that are incompatible with certain substrates/devices and/or do not provide adequate control over the resulting polymeric film. The provided method is advantageous in that it is applicable to fabrication of hybrid devices and is compatible with microfabrication technology, including that in clean-room settings.

Abstract: The present invention relates to a camera and a method for assembling a camera. The camera comprises a sensor, a lens, and a housing. The method comprises: adjusting a position of at least one of the sensor and the lens such that the sensor is positioned at a predetermined angle in relation to an optical axis of the lens, and laser welding the at least one of the sensor and the lens in relation to the housing such that the sensor and the lens are fixed in relation to each other.

Abstract: The present invention concerns an arrangement for the fastening of lift shaft equipment to a wall in a mine shaft for a personnel lift, the equipment comprising at least one rail that extends in the longitudinal direction of the shaft, on which rail a lift car can run, and fixtures for the mounting of the rail at a predetermined distance from the wall of the shaft. The fixture comprises an extended beam with means that can be adapted to the angular deviation of the wall of the shaft relative to the longitudinal direction of the beam.

Abstract: A method for solvent-less adhesive bonding is provided comprising depositing thin, functional, polymeric films on one or more substrates and bonding the substrates to each other or to other substrates. Depositing the polymeric films, including, for example, chemically reactive polymers and thermoplastics with adhesive qualities, may be accomplished using an initiated chemical vapor deposition technique compatible with a variety of monomers, including monomers with chemically functional moieties such as amine and epoxy groups. The technique allows for deposition of polymeric films on a wide variety of substrates/devices and provides an alternative for other coating/deposition methods that are incompatible with certain substrates/devices and/or do not provide adequate control over the resulting polymeric film. The provided method is advantageous in that it is applicable to fabrication of hybrid devices and is compatible with microfabrication technology, including that in clean-room settings.

Abstract: The present invention relates to methods of manufacture and utility of an artificial trabecular meshwork [TM] that utilizes micro- and nanofabricated materials bioengineered to mimic the structure and function of native outflow system of the eye.

Abstract: Polymer-based micro-cantilevers for depositing material onto a surface include, in one embodiment, a body portion, an elongated beam portion sized smaller than and extending from the body portion and having a length greater than about 500 microns. The body portion includes a reservoir and the elongated beam portion having a passageway disposed therein. The passageway has an inlet opening in fluid communication with the reservoir and an outlet opening at a distal end of the elongated beam portion. The passageway comprises a width greater than 10 microns to about 100 microns, and a height of about 25 microns to about 100 microns. Methods for delivering fluid and living cells using the polymer-based micro-cantilevers are also disclosed.

Abstract: Polymer-based micro-cantilevers for depositing material onto a surface include, in one embodiment, a body portion, an elongated beam portion sized smaller than and extending from the body portion and having a length greater than about 500 microns. The body portion includes a reservoir and the elongated beam portion having a passageway disposed therein. The passageway has an inlet opening in fluid communication with the reservoir and an outlet opening at a distal end of the elongated beam portion. The passageway comprises a width greater than 10 microns to about 100 microns, and a height of about 25 microns to about 100 microns. Methods for delivering fluid and living cells using the polymer-based micro-cantilevers are also disclosed.