Patents by Inventor Magnus Cernerud

Magnus Cernerud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE AND SALTS THEREOF
    Publication number: 20140329826
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 6, 2014
    Applicant: Proximagen Limited
    Inventors: Tom Fleck, Magnus Cernerud, Helena Lundstrom, Claes Lofstrom, Margit Pelcman, Alexander Paptchikhine, Emma Nylen, Alf Nygren
  • Pharmaceutical composition containing (2R)-methyl-1-3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinylpiperazine L-malate for treatment of serotonin-related diseases
    Patent number: 8835439
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: September 16, 2014
    Assignee: Proximagen Limited
    Inventors: Tom Fleck, Magnus Cernerud, Helena Lundstrom, Claes Lofstrom, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine and salts thereof
    Patent number: 8410113
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: April 2, 2013
    Assignee: Biovitrum AB (publ)
    Inventors: Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren, Bruce Fleck
  • (2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE AND SALTS THEREOF
    Publication number: 20120010410
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 12, 2012
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • SUCCINATE SALT OF (2R)-METHYL-1-PIPERAZINE
    Publication number: 20120004241
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 5, 2012
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Malate salt of (2R)-methyl-1-{3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinyl}piperazine
    Patent number: 8030316
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: October 4, 2011
    Assignee: Biovitrum AB (Publ)
    Inventors: Tom Fleck, Bruce Fleck, legal representative, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Phosphoric acid addition salt of (2R)-1-[3-(2-{[2-(2-dimethylaminoethoxy)-3-pyridinyl]oxy}-ethoxy)-2-pyrazinyl]-2-methylpiperazine
    Patent number: 7820677
    Abstract: Stable acid addition salts of certain 2,3-disubstituted pyrazine compounds that are selective for the 5-HT2c receptor and therapeutically active in the central nervous system are described.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: October 26, 2010
    Inventors: Tom Fleck, Bruce Fleck, legal representative, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • NOVEL PROCESS
    Publication number: 20100256374
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: June 17, 2010
    Publication date: October 7, 2010
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones
    Patent number: 7244722
    Abstract: Compounds of the general formula (I): wherein m, n, R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the preparation of a medicament for the treatment of 5-HT2A receptor-related disorders or medical conditions.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: July 17, 2007
    Assignee: Biovitrum AB
    Inventors: Magnus Cernerud, Helena Lundström, Björn M Nilsson, Markus Thor
  • Process for the preparation of stable acid addition salt of 2,3-disubstituted pyrazine compounds
    Patent number: 7129354
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1–R4 are each independently selected from the group consisting of hydrogen, halogen, C1–C6-alkyl, C1–C6-alkoxy, and di-C1–C6-alkylamino-C2–C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: October 31, 2006
    Assignee: Biovitrum AB
    Inventors: Bruce Fleck, legal representative, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren, Tom Fleck, deceased
  • Methods for producing oxirane carboxylic acids and derivatives thereof
    Patent number: 7078543
    Abstract: The invention relates to processes for preparing oxiranecarboxylic acids and derivatives thereof, in particular to processes which proceed under stereochemical control of the reaction steps, to the oxiranecarboxylic acids prepared according to the invention and derivatives thereof and to their use in pharmaceutical compositions, in particular for treating hyperlipaemia.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: July 18, 2006
    Assignee: MediGene Aktiengesellschaft
    Inventors: Magnus Cernerud, Kristina Berntsson
  • Novel process
    Publication number: 20060142578
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. (I)n one aspect, the invention relates to a process for the preparation of compounds of the general formula ((I)): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: February 22, 2006
    Publication date: June 29, 2006
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundstrom, Claes Lofstrom, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Methods for producing oxirane carboxylic acids and derivatives thereof
    Publication number: 20040236103
    Abstract: The invention relates to processes for preparing oxiranecarboxylic acids and derivatives thereof, in particular to processes which proceed under stereochemical control of the reaction steps, to the oxiranecarboxylic acids prepared according to the invention and derivatives thereof and to their use in pharmaceutical compositions, in particular for treating hyperlipaemia.
    Type: Application
    Filed: May 24, 2004
    Publication date: November 25, 2004
    Inventors: Magnus Cernerud, Kristina Berntsson
  • Compounds
    Publication number: 20040063693
    Abstract: Compounds of the general formula (I): 1
    Type: Application
    Filed: July 17, 2003
    Publication date: April 1, 2004
    Inventors: Magnus Cernerud, Helena Lundstrom, Bjorn M. Nilsson, Markus Thor
  • Novel Process
    Publication number: 20040038981
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system.
    Type: Application
    Filed: June 18, 2003
    Publication date: February 26, 2004
    Inventors: Bruce Fleck, Tom Fleck, Magnus Cernerud, Helena Lundstrom, Claes Lofstrom, Margit Pelcman, Alexander Paptchikhine, Emma Andrersson, Alf Nygren