Abstract: This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound of the invention is in particular considered useful for the treatment of central nervous system diseases and disorders which are responsive to modulation of GABAA receptors containing the ?5 subunit.

Abstract: A medicament delivery device includes a housing with a circle-segment-shaped compartment for a drive unit that moves at least one stopper in a medicament container and that includes a support wheel and central hub on which first and second parallel disks are fixedly attached and interconnected by an abutment cross-wall; spherical members between the abutment wall and adjacent the stopper; a clock spring within the hub with an outer end connected to the hub and an inner end connected to a one-direction-rotatable tubular hub coaxially arranged around a shaft fixedly attached to a housing part; and an activation member connected to the first disk by a hold-and-release mechanism. When the activation member is not depressed, the wheel and spring are held in a tensioned static state, and when the activation member is depressed, the spring and wheel are released and the spherical members are forced against the stopper.

Abstract: Disclosed herein are novel di-aromatic compounds of the general formula (I). Also pharmaceutical compositions comprising the novel compounds and the use of the novel compounds in treatment and prevention of diseases and disorders related to estrogen receptors are disclosed. Furthermore, methods for treating and preventing diseases and disorders related to estrogen receptors by administration of the novel compounds are disclosed.

Abstract: Disclosed herein are methods of treatment and prevention of diseases and disorders related to estrogen receptors comprising administering novel di-aromatic compounds to patients in need thereof.

Abstract: A method for transporting in a microfluidic conduit an aliquot of a liquid, possibly containing a substance I, which is dissolved in the liquid and typically exhibits charged groups and/or hydrophobic groups. The method is characterized in that the liquid contains an amphiphilic macromolecular substance.

Abstract: Provided is a medicament delivery device comprising an axially elongated housing, a coaxially extending plunger rod mounted with in the housing for expelling successive doses of medicament and rotateable about the axis. The plunger rod can be axially displaced from a ready-to-use position for expelling a dose of medicament to a non-ready-to-use position axially spaced from said ready-to-use position along the axis, and from said non-ready-to use position to a subsequent ready-to-use position angularly spaced from said non-ready-to use position about the axis The device further comprises an indicator member displaceably mounted onto the housing between a first angular position indicative of the ready-to-use positions and a second angular position indicative of the non-ready-to use positions.

Abstract: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.

Abstract: A medicament delivery device includes a housing with a circle-segment-shaped compartment for a drive unit that moves at least one stopper in a medicament container and that includes a support wheel and central hub on which first and second parallel disks are fixedly attached and interconnected by an abutment cross-wall; spherical members between the abutment wall and adjacent the stopper; a clock spring within the hub with an outer end connected to the hub and an inner end connected to a one-direction-rotatable tubular hub coaxially arranged around a shaft fixedly attached to a housing part; and an activation member connected to the first disk by a hold-and-release mechanism. When the activation member is not depressed, the wheel and spring are held in a tensioned static state, and when the activation member is depressed, the spring and wheel are released and the spherical members are forced against the stopper.

Abstract: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.

Abstract: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.

Abstract: Disclosed herein are methods of treatment and prevention of diseases and disorders related to estrogen receptors comprising administering novel di-aromatic compounds to patients in need thereof.

Abstract: An electromechanically operable parking brake system is provided for motor vehicles as well as to a respective method of operation The system includes, but is not limited to a brake device that is lockable by a brake module, a control unit that is electrically coupled to the brake module and further adapted to generate a first control signal for generating a first brake application force, and a safeguard mechanism is adapted to generate a second control signal for applying a second brake application force. The second brake application force is larger in magnitude than the first brake application force.

Abstract: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.

Abstract: A contact element that is arranged to follow, i.e. slide or roll, against a mating part includes a contact surface having a crowning profile on at least a part thereof. The crowning profile is defined by the function Y(X)=AX6 where Y is the crowning quantity, X is the distance from the centre of the contact surface of the contact element, A and B are real numbers and B is greater than 2.

Abstract: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.

Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

Abstract: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.

Abstract: The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

Abstract: Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.

Abstract: Described is method for preparing tertiary amines comprising sequential, exhaustive alkylation of a hydroxylamine derivative and cleavage of the O—N bond using the following steps: a) reacting the hydroxylamine derivative with an alkylating agent or with a carbonyl compound to form an oxime intermediate. b) reacting the oxime intermediate with a reducing agent to produce an alkylated derivative c) reacting the alkylated derivative with an alkylating agent or a carbonyl compound in the presence of a reducing agent to produce a dialkylated derivative d) reacting the dialkylated derivative with an alkylating agent to produce a quaternized derivative e) reacting the quaternized derivative with a reagent causing cleavage of the O—N bond to produce a tertiary amine.