Patents by Inventor Magnus Malmqvist

Magnus Malmqvist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150118694
    Abstract: A method for assessing if an individual or an animal has a selected condition includes: obtaining a biological sample from the individual or animal; detecting in a time-resolved manner the presence of a disease related target through use of a probe (111); calculating a multidimensional fingerprint (141) which represents the recorded binding curves (131); extracting a predefined region (151) or feature of the distribution; and using the region or feature to determine (170) if the individual or animal has the selected condition. The method is particularly advantageous for tissue slices combined with antibody probes, the antibody recognizing receptors known to be over-expressed in cancer. In even more particular, a method for the assessment of HER2 expression level in breast cancer is described.
    Type: Application
    Filed: May 30, 2013
    Publication date: April 30, 2015
    Applicant: RIDGEVIEW DIAGNOSTICS AB
    Inventors: Karl Andersson, Magnus Malmqvist, Lena Lebel, Hanna Bjorkelund, Lars Gedda
  • Patent number: 8709828
    Abstract: A method of analysis or diagnosis of solid objects is based on real-time detection of how predefined probes interact with structures present on or in the solid object combined with the calculation of how the recorded binding curves of said probes are distributed in terms of interaction properties. The interaction properties are input to a classification algorithm which automatically determines statues of the solid object. The method is particularly advantageous for solid biological objects like tissue slices combined with antibody probes, said antibody recognizing receptors known to be over-expressed in disease states on said tissue slice.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: April 29, 2014
    Assignee: Ridgeview Diagnostics AB
    Inventors: Karl Andersson, Magnus Malmqvist
  • Patent number: 8394646
    Abstract: A method for quality control of species used in analytical or diagnostic or therapeutic procedures includes immobilization of a model of the malignancy to a solid support (121), contacting the solid support with species dissolved in liquid (122), measuring both the rate of formation of complex and absolute magnitude of number of complexes of model and species (123) and determining the quality of species by comparing the measured values with predetermined values.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: March 12, 2013
    Assignee: Ridgeview Instruments AB
    Inventor: Magnus Malmqvist
  • Patent number: 8021626
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: September 20, 2011
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
  • Publication number: 20110195434
    Abstract: A method of analysis or diagnosis of solid objects is based on real-time detection of how predefined probes interact with structures present on or in the solid object combined with the calculation of how the recorded binding curves of said probes are distributed in terms of interaction properties. The interaction properties are input to a classification algorithm which automatically determines statues of the solid object. The method is particularly advantageous for solid biological objects like tissue slices combined with antibody probes, said antibody recognizing receptors known to be over-expressed in disease states on said tissue slice.
    Type: Application
    Filed: March 16, 2011
    Publication date: August 11, 2011
    Applicant: Ridgeview Instruments AB
    Inventors: Karl Andersson, Magnus Malmqvist
  • Publication number: 20100260642
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Application
    Filed: April 26, 2010
    Publication date: October 14, 2010
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg
  • Patent number: 7811515
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: October 12, 2010
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
  • Patent number: 7736587
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: June 15, 2010
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
  • Publication number: 20090263917
    Abstract: The invention relates to a method for quality control of species used in analytical or diagnostic or therapeutic procedures. It comprises immobilization of a model of the malignancy to a solid support (121), contacting the solid support with species dissolved in liquid (122), measuring both the rate of formation of complex and absolute magnitude of number of complexes of model and species (123) and determining the quality of species by comparing the measured values with predetermined values.
    Type: Application
    Filed: June 23, 2009
    Publication date: October 22, 2009
    Inventor: Magnus Malmqvist
  • Publication number: 20090263285
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 22, 2009
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
  • Publication number: 20090263284
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 22, 2009
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: MAGNUS MALMQVIST, Hakan Roos, Stefen Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
  • Patent number: 7582487
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 1, 2009
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg
  • Patent number: 7122646
    Abstract: Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: October 17, 2006
    Assignee: Medical Research Council
    Inventors: Kaspar-Philipp Holliger, Andrew David Griffiths, Hendricus Renerus Jacobus Matheus Hoogenboom, Magnus Malmqvist, James David Marks, Brian Timothy McGuinness, Anthony Richard Pope, Terence Derek Prospero, Gregory Paul Winter
  • Patent number: 7105356
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: September 12, 2006
    Assignee: Biacore AB
    Inventors: Magnus Malmqvist, H{dot over (a)}kan Roos, Stefan Sjölander, Mattias Tidare, H{dot over (a)}kan Sjödin, Ralph St{dot over (a)}lberg
  • Publication number: 20060160687
    Abstract: Rapid mixing and homogenisation of reaction mixtures with respect to temperature and chemical concentrations, as well as greatly enhanced mass transport is achieved when the reaction mixture placed in a vassel suitable for centrifugation, and subjected to asymmetric heating, cooling and simultaneous centrifugation at conditions for creating an enhanced flow within the reaction mixture, wherein the flow ensures practically total mixing and homogenisation of the reaction mixture.
    Type: Application
    Filed: November 18, 2003
    Publication date: July 20, 2006
    Inventors: Mats Malmqvist, Nicke Svanvik, Magnus Malmqvist
  • Publication number: 20060134800
    Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
    Type: Application
    Filed: December 6, 2005
    Publication date: June 22, 2006
    Applicant: Biacore AB
    Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
  • Patent number: 6844201
    Abstract: Methods for capturing analytes associated with surface-bound ligands are disclosed. The methods involve eluting analytes from surface-bound ligands with a first liquid to generate free analytes, and capturing the free analytes with a solid capturing material within the first liquid to generate a first liquid containing captured analytes. The first liquid may be a flowing liquid or a non-flowing liquid, and the surface to which the surface-bound ligand is attached may be a sensing surface, such as a biosensor, or a non-sensing surface. The captured analytes may be further consolidated at a location removed from the surface-bound ligand, eluted from the solid capturing material with a second liquid, and used for subsequent analysis or procedures.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: January 18, 2005
    Assignee: Biacore AB
    Inventors: Magnus Malmqvist, Östen Jansson
  • Publication number: 20040058400
    Abstract: Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.
    Type: Application
    Filed: September 20, 2002
    Publication date: March 25, 2004
    Applicant: Medical Research Council
    Inventors: Kaspar-Philipp Holliger, Andrew David Griffiths, Hendricus Renerus Jacobus Matheus Hoogenboom, Magnus Malmqvist, James David Marks, Brian Timothy McGuinness, Anthony Richard Pope, Terence Derek Prospero, Gregory Paul Winter
  • Publication number: 20030077842
    Abstract: Methods for capturing analytes associated with surface-bound ligands are disclosed. The methods involve eluting analytes from surface-bound ligands with a first liquid to generate free analytes, and capturing the free analytes with a solid capturing material within the first liquid to generate a first liquid containing captured analytes. The first liquid may be a flowing liquid or a non-flowing liquid, and the surface to which the surface-bound ligand is attached may be a sensing surface, such as a biosensor, or a non-sensing surface. The captured analytes may be further consolidated at a location removed from the surface-bound ligand, eluted from the solid capturing material with a second liquid, and used for subsequent analysis or procedures.
    Type: Application
    Filed: November 15, 2002
    Publication date: April 24, 2003
    Applicant: Biacore AB
    Inventors: Magnus Malmqvist, Osten Jansson
  • Patent number: 6503760
    Abstract: Methods for capturing analytes associated with surface-bound ligands are disclosed. The methods involve eluting analytes from surface-bound ligands with a first liquid to generate free analytes, and capturing the free analytes with a solid capturing material within the first liquid to generate a first liquid containing captured analytes. The first liquid may be a flowing liquid or a non-flowing liquid, and the surface to which the surface-bound ligand is attached may be a sensing surface, such as a biosensor, or a non-sensing surface. The captured analytes may be further consolidated at a location removed from the surface-bound ligand, eluted from the solid capturing material with a second liquid, and used for subsequent analysis or procedures.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: January 7, 2003
    Assignee: Biacore AB
    Inventors: Magnus Malmqvist, Östen Jansson