Abstract: The present invention relates to a solution for nanoplasmonic measurement using a nanoplasmonic device with a short range order structure of trough going channels in contact with a fluid flow cell. The device is manufactured in a micro machine process comprising steps of using combined colloidal lithography, thin film deposition and etching steps on the micro/nano scale, for chemical or bio analytical sensing, and other uses. The solution makes use of shifts in the nanoplasmonic resonance, an optical property of the device that is sensitive to changes in refractive index induced by molecular reactions or other processes.