Abstract: A method for improving reliability of an integrity or leak test includes determining at least one first parameter indicative of: a first volume of a sample, a first temperature of the sample, a first pressure of the sample and/or a first assessment of integrity of the sample. The method further determines at least one second parameter indicative of a deviation from the first parameter and at least one third parameter indicative of a second assessment of the integrity of the sample. The second assessment provides an indication of a passed or failed test. The method further determines whether the deviation has an impact on the indication of the second assessment. When the deviation is determined to have an impact on the indication of the second assessment, the method comprises identifying a possibility that the indication of the second assessment is incorrect.

Abstract: A method for improving reliability of an integrity or leak test includes determining at least one first parameter indicative of: a first volume of a sample, a first temperature of the sample, a first pressure of the sample and/or a first assessment of integrity of the sample. The method further determines at least one second parameter indicative of a deviation from the first parameter and at least one third parameter indicative of a second assessment of the integrity of the sample. The second assessment provides an indication of a passed or failed test. The method further determines whether the deviation has an impact on the indication of the second assessment. When the deviation is determined to have an impact on the indication of the second assessment, the method comprises identifying a possibility that the indication of the second assessment is incorrect.

Abstract: A method for calibrating a pressure sensor includes connecting the pressure sensor to first and second fluid storage vessels; providing an initial fluid pressure at the pressure sensor and at the fluid storage vessels; and carrying out a pressure measurement of the initial fluid pressure at a time t0. The method then disconnects the second fluid storage vessel from the pressure sensor and the first fluid storage vessel; provides a first fluid pressure at the second fluid storage vessel; and carries out a pressure measurement of the first fluid pressure at a time t1. The method then connects the second fluid storage vessel with the pressure sensor and the first fluid storage vessel, so that a second fluid pressure between the initial and first fluid pressures is provided at the pressure sensor; and carries out a pressure measurement of the second fluid pressure at a time t2.

Abstract: A method for calibrating a pressure sensor includes connecting the pressure sensor to first and second fluid storage vessels; providing an initial fluid pressure at the pressure sensor and at the fluid storage vessels; and carrying out a pressure measurement of the initial fluid pressure at a time t0. The method then disconnects the second fluid storage vessel from the pressure sensor and the first fluid storage vessel; provides a first fluid pressure at the second fluid storage vessel; and carries out a pressure measurement of the first fluid pressure at a time t1. The method then connects the second fluid storage vessel with the pressure sensor and the first fluid storage vessel, so that a second fluid pressure between the initial and first fluid pressures is provided at the pressure sensor; and carries out a pressure measurement of the second fluid pressure at a time t2.

Abstract: An apparatus automatically carries out an integrity test on a filter device having a fluid inlet, a fluid outlet and a venting port. The apparatus includes a filter integrity testing device having a pressure sensor and/or a flowmeter. An inlet connector is connectable to the fluid inlet, is connected via a wetting liquid supply valve to a wetting liquid supply, and is connected via a drainage valve to a first drain. An outlet connector is connectable to the fluid outlet and via an outlet valve to the first or a second drain. A venting port connector is connectable to the venting port and via a measurement valve to the pressure sensor and/or flowmeter. The venting port connector also is connected via a venting valve to a venting pipe, and via a measurement gas valve to a measurement gas source. The valves are controlled by the filter integrity testing device.

Abstract: There is a bag (1) that has at least one lateral gusset (4) and at least one port (8), a source (10) of pressurized gas, elements (11) for measuring the pressure of the gas; —there are two restraining plates and spacer strips. The bag is placed flat between the two restraining plates (2a, 2b). At least one spacer strip (15a, 15b) is inserted between the two small walls of each gusset in order to prevent these walls from resting on one another. The port is connected to the gas source and the pressure measuring elements. The gas is sent under pressure into the bag, the expansion of the bag being limited by the restraining plates; then, the pressure drop in the bag is compared to a predefined threshold.

Abstract: An apparatus automatically carries out an integrity test on a filter device having a fluid inlet, a fluid outlet and a venting port. The apparatus includes a filter integrity testing device having a pressure sensor and/or a flowmeter. An inlet connector is connectable to the fluid inlet, is connected via a wetting liquid supply valve to a wetting liquid supply, and is connected via a drainage valve to a first drain. An outlet connector is connectable to the fluid outlet and via an outlet valve to the first or a second drain. A venting port connector is connectable to the venting port and via a measurement valve to the pressure sensor and/or flowmeter. The venting port connector also is connected via a venting valve to a venting pipe, and via a measurement gas valve to a measurement gas source. The valves are controlled by the filter integrity testing device.

Abstract: There is a bag (1) that has at least one lateral gusset (4) and at least one port (8), a source (10) of pressurized gas, elements (11) for measuring the pressure of the gas; —there are two restraining plates and spacer strips. The bag is placed flat between the two restraining plates (2a, 2b). At least one spacer strip (15a, 15b) is inserted between the two small walls of each gusset in order to prevent these walls from resting on one another. The port is connected to the gas source and the pressure measuring elements. The gas is sent under pressure into the bag, the expansion of the bag being limited by the restraining plates; then, the pressure drop in the bag is compared to a predefined threshold.

Abstract: A method is made available for conducting an integrity test of filter elements (3), in particular of sterile filters. The integrity test involves direct measurement, at constant pressure, of a liquid flow on the inflow side of the filter element (3) to be tested. The test method is practically independent of changing environmental conditions, provides a result which is not distorted by a change of pressure on the inflow side of the filter element, and permits a very short measurement time.

Abstract: A method is made available for conducting an integrity test of filter elements (3), in particular of sterile filters. The integrity test involves direct measurement, at constant pressure, of a liquid flow on the inflow side of the filter element (3) to be tested. The test method is practically independent of changing environmental conditions, provides a result which is not distorted by a change of pressure on the inflow side of the filter element, and permits a very short measurement time.