Abstract: The present disclosure generally relates to a method for COVID-19 detection for spread prevention and medical assistance using machine learning comprises pre-processing a CT image set for removing noise using HU values; performing a region-based segmentation using a three-dimensional convolutional neural network model; classifying each segmented region by employing a classification model; and comparing classified segmented region with a dataset for detecting COVID-19 using a machine learning approach thereby generating an alert about the COVID-19 positive person.