Patents by Inventor Mahadevan Bhupathy

Mahadevan Bhupathy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of leukotriene antagonists
    Patent number: 6320052
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercapto-methyl)cyclopropaneacetic acid with a compound of formula (II) wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: November 20, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mahadevan Bhupathy, Daniel R. Sidler, James M. McNamara, Ralph P. Volante, James Bergan
  • Process for the synthesis of N-benzyl-3-(4-fluorophenyl)-1-4-oxazin-2-one
    Patent number: 6177564
    Abstract: The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of the formula: This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: January 23, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Todd D. Nelson, Mahadevan Bhupathy
  • Process for the preparation of leukotriene anatgonists
    Patent number: 5614632
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof ##STR1## wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercaptomethyl)cyclopropaneacetic acid with a compound of formula (II) ##STR2## wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: March 25, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Mahadevan Bhupathy, James M. McNamara, Daniel R. Sidler, Ralph P. Volante, James Bergan
  • Method for brevicomin synthesis and use in beetle control
    Patent number: 4609743
    Abstract: A process for the production of the beetle aggregation pheromone brevicomin comprising reacting acrolein dimer sequentially with ethyllithium, a methylating agent and aqueous protonic acid. In a modification of the process the acrolein dimer is reacted with ethyl Grignard reagent prior to reaction with an alkyllithium compound. The process includes distributing the brevicomin product to areas to be controlled for beetles.
    Type: Grant
    Filed: April 17, 1984
    Date of Patent: September 2, 1986
    Assignee: University of Pittsburgh
    Inventors: Theodore Cohen, Mahadevan Bhupathy