Patents by Inventor Mahantesh Navati

Mahantesh Navati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sol-gel/hydrogel therapeutic delivery system and methods thereof
    Patent number: 12186435
    Abstract: Disclosed herein is a delivery platform for the preparation of versatile sol-gel/hydrogel based nano and micro particles that can be loaded with small molecules. The delivery platform is suitable for topical, transdermal, IV, IP and aerosol drug delivery. Also disclosed herein are methods of treatment using the aforementioned particles.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: January 7, 2025
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Joel Friedman, Andrew Draganski, Adam Friedman, Mahantesh Navati, Parimala Nacharaju
  • Sol-Gel/Hydrogel Therapeutic Delivery System and Methods Thereof
    Publication number: 20200030247
    Abstract: Disclosed herein is a delivery platform for the preparation of versatile sol-gel/hydrogel based nano and micro particles that can be loaded with small molecules. The delivery platform is suitable for topical, transdermal, IV, IP and aerosol drug delivery. Also disclosed herein are methods of treatment using the aforementioned particles.
    Type: Application
    Filed: February 9, 2018
    Publication date: January 30, 2020
    Inventors: JOEL FRIEDMAN, ANDREW DRAGANSKI, ADAM FRIEDMAN, MAHANTESH NAVATI, PARIMALA NACHARAJU
  • Nanoparticle Compositions and Methods Thereof to Restore Vascular Integrity
    Publication number: 20180256509
    Abstract: The present invention relates to methods for treating systemic inflammation. In certain embodiments, the method comprises administering a therapeutically effective amount of curcumin-selenium loaded nanoparticles. The curcumin-selenium loaded nanoparticles can comprise a matrix of chitosan, polyethylene glycol and tetramethoxysilane encapsulating curcumin and selenium. In certain embodiments, the method comprises administering a therapeutically effective amount of nitric oxide-releasing nanoparticles. The nitric oxide-releasing nanoparticles can comprise a matrix of chitosan encapsulating nitric oxide. In certain embodiments, the systemic inflammation can be caused by endotoxemia. In certain embodiments, the systemic inflammation can be caused by a Filovirus, including an Ebola virus or a Marburg virus. In certain embodiments, the methods for treating systemic inflammation in a subject result in the reduction of proinflammatory cytokines in a subject.
    Type: Application
    Filed: November 3, 2015
    Publication date: September 13, 2018
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., UNIVERSITY OF CALIFORNIA SAN DIEGO
    Inventors: Joel M. Friedman, Mahantesh Navati, Adam J. Friedman, Pedro Cabrales
  • Stable Oxidation Resistant Powdered Hemoglobin, Methods of Preparing Same, and Uses Thereof
    Publication number: 20080039370
    Abstract: The present invention provides oxygenated hemoglobins in powdered form and methods of preparing a powdered form of a protein, such as hemoglobin, which comprise (a) mixing a solution of the protein with inulin, and optimally with a reducing sugar such as glucose or tagatose, and (b) drying the mixture. Also provided are blood substitutes formed from reconstituted powdered hemoglobins, and methods of treatment using the blood substitutes.
    Type: Application
    Filed: April 20, 2005
    Publication date: February 14, 2008
    Inventors: Joel Friedman, Mahantesh Navati