Patents by Inventor Mahbod Hajivandi
Mahbod Hajivandi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10753905Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: GrantFiled: May 17, 2017Date of Patent: August 25, 2020Inventors: John Leite, Robert Pope, Mahbod Hajivandi, Xiquan Liang
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Publication number: 20170254775Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: ApplicationFiled: May 17, 2017Publication date: September 7, 2017Inventors: John LEITE, Robert POPE, Mahbod HAJIVANDI, Xiquan LIANG
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Patent number: 9733213Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: GrantFiled: July 25, 2013Date of Patent: August 15, 2017Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: John Leite, Robert Pope, Mahbod Hajivandi, Xiquan Liang
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Publication number: 20140065625Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: ApplicationFiled: July 25, 2013Publication date: March 6, 2014Applicant: LITE TECHNOLOGIES CORPORATIONInventors: John Leite, Robert Pope, Mahbod Hajivandi, Xiquan Liang
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Publication number: 20120258877Abstract: Methods are provided for identifying proteins that are differentially expressed in disease state and normal cells. Stable isotope labeling of cells in culture allows for the identification of a multiplicity of proteins whose differential abundance in normal and disease state cells can be indicative of the disease state. Biomarkers are identified for breast cancer, in which the biomarkers are proteins having a two-fold or greater difference in abundance between breast cancer and normal cells. Identified biomarkers can be used detection methods that can provide diagnosis, typing, staging, or prognosis of cancer, such as breast cancer, or can be used to predict the response of cancer, such as breast cancer, to one or more anti-cancer agents.Type: ApplicationFiled: February 9, 2011Publication date: October 11, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Robert M. POPE, Xiquan Liang, Mahbod Hajivandi, John Leite
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Publication number: 20110315930Abstract: Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).Type: ApplicationFiled: December 16, 2010Publication date: December 29, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Robert Marshall Pope, John Leite, Mahbod Hajivandi, Charles George Shevlin, Timothy Updyke
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Publication number: 20110262947Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: ApplicationFiled: April 22, 2011Publication date: October 27, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: John F. Leite, Robert Marshall Pope, Mahbod Hajivandi, Xiquan Liang
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Patent number: 7939331Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: GrantFiled: March 7, 2006Date of Patent: May 10, 2011Assignee: Life Technologies CorporationInventors: John F. Leite, Robert Marshall Pope, Mahbod Hajivandi, Xiquan Liang
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Publication number: 20100187475Abstract: Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).Type: ApplicationFiled: September 2, 2009Publication date: July 29, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Robert Marshall Pope, John Leite, Mahbod Hajivandi, Charles George Shevlin, Timothy Updyke
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Publication number: 20090226913Abstract: Methods are provided for identifying proteins that are differentially expressed in disease state and normal cells. Stable isotope labeling of cells in culture allows for the identification of a multiplicity of proteins whose differential abundance in normal and disease state cells can be indicative of the disease state. Biomarkers are identified for breast cancer, in which the biomarkers are proteins having a two-fold or greater difference in abundance between breast cancer and normal cells. Identified biomarkers can be used detection methods that can provide diagnosis, typing, staging, or prognosis of cancer, such as breast cancer, or can be used to predict the response of cancer, such as breast cancer, to one or more anti-cancer agents.Type: ApplicationFiled: December 19, 2008Publication date: September 10, 2009Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Robert M. Pope, Xiquan Liang, Mahbod Hajivandi, John Leite
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Publication number: 20070105181Abstract: Methods are provided for identifying proteins that are differentially expressed in disease state and normal cells. Stable isotope labeling of cells in culture allows for the identification of a multiplicity of proteins whose differential abundance in normal and disease state cells can be indicative of the disease state. Biomarkers are identified for breast cancer, in which the biomarkers are proteins having a two-fold or greater difference in abundance between breast cancer and normal cells. Identified biomarkers can be used detection methods that can provide diagnosis, typing, staging, or prognosis of cancer, such as breast cancer, or can be used to predict the response of cancer, such as breast cancer, to one or more anti-cancer agents.Type: ApplicationFiled: May 4, 2006Publication date: May 10, 2007Applicant: Invitrogen CorporationInventors: Robert Pope, Xiquan Liang, Mahbod Hajivandi, John Leite
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Publication number: 20070031911Abstract: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.Type: ApplicationFiled: March 7, 2006Publication date: February 8, 2007Inventors: John Leite, Robert Pope, Mahbod Hajivandi, Xiquan Liang
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Publication number: 20060214104Abstract: Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).Type: ApplicationFiled: October 26, 2005Publication date: September 28, 2006Applicant: Invitrogen CorporationInventors: Robert Pope, John Leite, Mahbod Hajivandi, Charles Shevlin, Timothy Updyke
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Publication number: 20060023808Abstract: The invention provides compositions, kits, and methods for calibrating a mass spectrometer using two or more recombinant proteins and one or more energy-absorbing molecules. The recombinant proteins of the invention display high purities, making them suitable for use in mass spectrometry.Type: ApplicationFiled: May 17, 2005Publication date: February 2, 2006Inventors: Mahbod Hajivandi, Robert Pope, Mehrnoosh Sadeghi, Xiquan Liang, John Leite