Patents by Inventor Mahboubeh KHEIRABADI

Mahboubeh KHEIRABADI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250051393
    Abstract: Compounds that include a cyclic cell penetrating peptide and a therapeutic moiety modulates Interferon Regulatory Factor-5 (IRF-5) activity in an immune cell. The therapeutic moiety is a therapeutic protein, a small molecule, or an antisense compound. Methods include administering the compound to cells or subjects to modulate IRF-5 activity. Methods include treating diseases associated with IRF-5 using the compounds.
    Type: Application
    Filed: May 9, 2022
    Publication date: February 13, 2025
    Inventors: Ziqing QIAN, Natarajan SETHURAMAN, Mahboubeh KHEIRABADI, Haoming LIU, Xiulong SHEN, Xiang LI
  • Publication number: 20250011774
    Abstract: Compounds comprising a cyclic peptide, such as a cyclic cell penetrating peptide, and an antisense compound are provided. The antisense compound binds to a gene having an expanded CTG repeat or a gene transcript having an expanded CUG repeat. The compounds can be delivered to subjects to treat diseases associated with expanded CTG CUG repeats, such as myotonic dystrophy type 1 (DM1), spinocerebellar ataxia-8 (SCA8), and Huntington disease like-2 (HDL2).
    Type: Application
    Filed: December 20, 2023
    Publication date: January 9, 2025
    Inventors: Xiulong SHEN, Ziqing QIAN, Patrick DOUGHERTY, Mahboubeh KHEIRABADI, Xiang LI
  • Publication number: 20240417429
    Abstract: Described herein in various embodiments are compositions comprising (a) a cell penetrating peptide (CPP) sequence; and (b) an antisense compound, wherein the antisense compound targets exon 45 of the DMD gene.
    Type: Application
    Filed: August 30, 2022
    Publication date: December 19, 2024
    Inventors: Xiang Li, Ziqing Qian, Mahboubeh Kheirabadi, Ming Zhou, Mahsweta Girgenrath, Nelsa Estrella, Suresh Peddigari, Anushree Pathak, Natarajan Sethuraman, Wenlong Lian, Nanjun Liu
  • Publication number: 20240358845
    Abstract: Provided herein are compounds that include a cyclic cell penetrating peptide, a therapeutic moiety and a modulatory peptide, wherein the modulatory peptide modulates the tissue distribution and/or retention of the compound in vivo. Also provide herein are methods of modulating tissue distribution and/or retention of intracellular therapeutics using the aforementioned compounds.
    Type: Application
    Filed: May 9, 2022
    Publication date: October 31, 2024
    Inventors: Ziqing Qian, Patrick Dougherty, Mahboubeh Kheirabadi, Haoming Liu, Xiulong Shen, Xiang Li
  • Publication number: 20240245790
    Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.
    Type: Application
    Filed: November 9, 2023
    Publication date: July 25, 2024
    Inventors: Ziqing Qian, Patrick Dougherty, Mahboubeh Kheirabadi, Haoming Liu, Xiulong Shen
  • Patent number: 12018097
    Abstract: The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I): prior to cleavage of the peptide from the solid phase support.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: June 25, 2024
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gardner S. Creech, Mahboubeh Kheirabadi, Martin D. Eastgate, David S. Nirschl, Percy H Carter
  • Publication number: 20240051996
    Abstract: The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis.
    Type: Application
    Filed: September 13, 2022
    Publication date: February 15, 2024
    Inventors: Gardner S. CREECH, Mahboubeh KHEIRABADI, Martin D. EASTGATE, David S. NIRSCHL, Percy H. CARTER
  • Publication number: 20230312653
    Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.
    Type: Application
    Filed: March 30, 2023
    Publication date: October 5, 2023
    Inventors: Patrick Dougherty, Ziqing Qian, Mahboubeh Kheirabadi
  • Publication number: 20230020092
    Abstract: Provided herein are compounds comprising cyclic cell penetrating peptides and antisense compounds. Also provided herein are methods of modulating splicing, inhibiting or regulating translation, mediating degradation, blocking expansions of nucleotide repeats, and treating disease using the aforementioned compounds.
    Type: Application
    Filed: December 21, 2020
    Publication date: January 19, 2023
    Inventors: Ziqing Qian, Xiang Li, Mahboubeh Kheirabadi, Mohanraj Dhanabal, Haoming Liu, Xiulong Shen, Kimberli Kamer, Natarajan Sethuraman
  • Publication number: 20230000960
    Abstract: Disclosed herein relates to immunotherapeutic polypeptides comprising neoepitopes, antigen presenting cells comprising the immunotherapeutic polypeptides, and a pharmaceutical composition comprising the immunotherapeutic polypeptides. Also disclosed herein is use of the immunotherapeutic polypeptides in treating a disease or condition.
    Type: Application
    Filed: June 10, 2020
    Publication date: January 5, 2023
    Inventors: Vikram Juneja, Zhengxin Dong, Robyn Jessica Eisert, Mahboubeh Kheirabadi
  • Patent number: 11479581
    Abstract: The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving the capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: October 25, 2022
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Gardner S. Creech, Mahboubeh Kheirabadi, Martin D. Eastgate, David S. Nirschl, Percy H. Carter
  • Publication number: 20210079046
    Abstract: The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving said capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.
    Type: Application
    Filed: June 8, 2018
    Publication date: March 18, 2021
    Inventors: Gardner S. CREECH, Mahboubeh KHEIRABADI, Martin D. EASTGATE, David S. NIRSCHIL, Percy H. CARTER