Patents by Inventor Mahendar Reddy Nayini

Mahendar Reddy Nayini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of valsartan
    Patent number: 8981109
    Abstract: The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4?-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2?-(2-tributyltintetrazol-5-yl
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 17, 2015
    Assignee: Aurobindo Pharma Ltd
    Inventors: Raveendra Reddy Chinta, Gangadhara Bhima Shankar Nangi, Mahendar Reddy Nayini, Somappa Somannavar Yallapa, Shankar Reddy Budidet, Islam Aminul, Sivakumaran Meenakshisunderam
  • PROCESS FOR THE PREPARATION OF VALSARTAN
    Publication number: 20130144067
    Abstract: The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4?-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2?-(2-tributyltinte-trazol-5-y
    Type: Application
    Filed: June 24, 2011
    Publication date: June 6, 2013
    Inventors: Raveendra Reddy Chinta, Gangadhara Bhima Shankar Nangi, Mahendar Reddy Nayini, Somappa Somannavar Yallapa, Shankar Reddy Budidet, Islam Aminul, Sivakumaran Meenakshisunderam