Patents by Inventor Mahendra Dedhiya

Mahendra Dedhiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Delayed Release Compositions of Linaclotide
    Publication number: 20230398173
    Abstract: The present invention relates to delayed release pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: August 28, 2023
    Publication date: December 14, 2023
    Inventors: Angelika Fretzen, Mark G. Currie, Ahmad Hashash, Mahendra Dedhiya, Yun Mo, Anil Chhettry, Matthew Miller, Ritesh Sanghvi, Mohammad Mafruhul Bari, Andreas Grill
  • Stable Formulations of Linaclotide
    Publication number: 20230346881
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: July 7, 2023
    Publication date: November 2, 2023
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Stable Solid Formulation of GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
    Publication number: 20230310329
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: April 14, 2023
    Publication date: October 5, 2023
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Delayed Release Compositions of Linaclotide
    Publication number: 20230142270
    Abstract: The present invention relates to delayed release pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: December 30, 2022
    Publication date: May 11, 2023
    Inventors: Angelika Fretzen, Mark G. Currie, Ahmad Hashash, Mahendra Dedhiya, Yun Mo, Anil Chhettry, Matthew Miller, Ritesh Sanghvi, Mohammad Mafruhul Bari, Andreas Grill
  • Stable Formulations of Linaclotide
    Publication number: 20220233635
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: April 14, 2022
    Publication date: July 28, 2022
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Stable Solid Formulation of GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
    Publication number: 20220125734
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 28, 2022
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
    Publication number: 20210290554
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: June 2, 2021
    Publication date: September 23, 2021
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Stable formulations of linaclotide
    Patent number: 10702576
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: July 7, 2020
    Assignees: IRONWOOD PHARMACEUTICALS, INC., FOREST LABORATORIES HOLDINGS LIMITED
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Stable formulations of linaclotide
    Patent number: 10675325
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: June 9, 2020
    Assignees: IRONWOOD PHARMACEUTICALS, INC., FOREST LABORATORIES HOLDINGS LIMITED
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Stable Formulations of Linaclotide
    Publication number: 20200030407
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 30, 2020
    Inventors: YUN MO, ANGELIKA FRETZEN, BRIAN CALI, MAHENDRA DEDHIYA
  • Stable Formulations of Linaclotide
    Publication number: 20200009216
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: September 19, 2019
    Publication date: January 9, 2020
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Stable Formulations of Linaclotide
    Publication number: 20190209644
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: January 17, 2019
    Publication date: July 11, 2019
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Stable Solid Formulation of GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
    Publication number: 20190029967
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: September 13, 2018
    Publication date: January 31, 2019
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Delayed Release Compositions of Linaclotide
    Publication number: 20160310559
    Abstract: The present invention relates to delayed release pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: December 11, 2014
    Publication date: October 27, 2016
    Inventors: Angelika Fretzen, Mark G. Currie, Ahmad Hashash, Mahendra Dedhiya, Yun Mo, Anil Chhettry, Matthew Miller, Ritesh Sanghvi, Mohammad Mafruhul Bari, Andreas Grill
  • Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
    Publication number: 20150132375
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Orally Disintegrating Compositions of Linaclotide
    Publication number: 20150031632
    Abstract: The present invention relates to orally disintegrating or dissolving pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: October 9, 2014
    Publication date: January 29, 2015
    Inventors: YUN MO, MAHENDRA DEDHIYA, ANIL CHHETTRY, ANGELIKA FRETZEN, STEVEN WITOWSKI, ALFREDO GROSSI, HONG ZHAO
  • Stable Formulations of Linaclotide
    Publication number: 20140378393
    Abstract: The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Inventors: Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
  • Treatment of Chronic Constipation
    Publication number: 20140349948
    Abstract: The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide.
    Type: Application
    Filed: December 23, 2013
    Publication date: November 27, 2014
    Applicants: Forest Laboratories Holdings Limited, Ironwood Pharmaceuticals, Inc.
    Inventors: Jeffrey Johnston, Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Bernard Joseph Lavins, Mahendra Dedhiya, Harvey Schneier
  • Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
    Publication number: 20140287034
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 25, 2014
    Applicants: Ironwood Pharmaceuticals, Inc., Forest Laboratories Holdings Limited
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
  • Stable solid formulation of a GC-C receptor agonist polypeptide suitable for oral administration
    Patent number: 8802628
    Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: August 12, 2014
    Assignees: Ironwood Pharmaceuticals, Inc., Forest Laboratories Holdings, Ltd.
    Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo