Abstract: This invention relates to a nucleotide array containing polynucleotide probes complementary to, or fragments of, Cynomolgus monkey genes, and the use of such a nucleotide array to characterize the biological effects, including the actions, targets, and toxicities, of therapeutic agents in primates, e.g., a human, a Cynomolgus monkey, or a Rhesus monkey, in particular a nucleotide array to be used in identifying the toxicities of therapeutic agents administered to a non-human primate, e.g., a Cynomolgus monkey or a Rhesus monkey.

Abstract: The invention provides toxicity predictive genes that can be used to predict toxicity in response to one more agents. The invention provides for a method of predicting the liver toxicity in an individual to an agent. The method comprises obtaining a biological sample from an individual treated with the agent. The expression of one or more liver toxicity predictive genes in the sample is measured, wherein the genes are selected from a group consisting of partial gene sequences of genes identified as responsive to agents causing liver necrosis. The process generates a test expression profile. The test expression profile is used with a set of reference expression profiles in a Predictive Model to determine whether the agent will induce liver toxicity in the individual.

Abstract: The invention provides toxicity predictive genes that can be used to predict toxicity in response to one more agents. The invention provides for a method of predicting the liver toxicity In Vivo or In Vitro to an agent. The method comprises obtaining a biological sample from an individual, cell culture or explant treated with the agent. The expression of one or more liver toxicity predictive genes in the sample is measured, wherein the genes are selected from a group consisting of partial gene sequences of genes identified as responsive to agents causing liver inflammation. The process generates a test expression profile. The test expression profile is used with a set of reference expression profiles in a Predictive Model to determine whether the agent will induce liver toxicity in the individual.