Patents by Inventor Mahesh Chaubal

Mahesh Chaubal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Surfactant systems for delivery of organic compounds
    Patent number: 9700866
    Abstract: Submicron particles of an organic compound, such as therapeutic and diagnostic agent are disclosed. The organic compound particles are associated with at least two surfactants including a block copolymer and phospholipids conjugated with a hydrophilic polymer.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: July 11, 2017
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Mahesh Chaubal, Mark J. Doty, Jamie T. Konkel, Barrett E. Rabinow
  • Method for preparing submicron particles of antineoplastic agents
    Patent number: 8067032
    Abstract: The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: November 29, 2011
    Assignee: Baxter International Inc.
    Inventors: Mahesh Chaubal, Jane Werling, Barrett Rabinow
  • Surfactant systems for delivery of organic compounds
    Publication number: 20060073199
    Abstract: Submicron particles of an organic compound, such as therapeutic and diagnostic agent are disclosed. The organic compound particles are associated with at least two surfactants including a block copolymer and phospholipids conjugated with a hydrophilic polymer.
    Type: Application
    Filed: September 12, 2005
    Publication date: April 6, 2006
    Inventors: Mahesh Chaubal, Mark Doty, Jamie Konkel, Barrett Rabinow
  • Nanosuspensions of anti-retroviral agents for increased central nervous system delivery
    Publication number: 20050202094
    Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.
    Type: Application
    Filed: January 21, 2005
    Publication date: September 15, 2005
    Inventors: Jane Werling, Mahesh Chaubal, James Kipp, Barrett Rabinow
  • Phosphorous-containing compounds with polymeric chains, and methods of making and using the same
    Publication number: 20050182236
    Abstract: The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
    Type: Application
    Filed: February 25, 2003
    Publication date: August 18, 2005
    Applicant: Guilford Pharmaceuticals, Inc.
    Inventors: Keith Branham, Mahesh Chaubal, James English, Donna Hall, Zhong Zhao
  • Process for production of essentially solvent-free small particles
    Publication number: 20040256749
    Abstract: The present invention is concerned with the formation of small particles of an organic compound by mixing a solution of the organic compound dissolved in a water-miscible organic solvent with an aqueous medium to form a mix and simultaneously homogenizing the mix while continuously removing the organic solvent to form an aqueous suspension of small particles essentially free of the organic solvent. These processes are preferably used to prepare an aqueous suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrative route such as parenteral, oral, pulmonary, nasal, buccal, topical, ophthalmic, rectal, vaginal, transdermal or the like.
    Type: Application
    Filed: October 29, 2003
    Publication date: December 23, 2004
    Inventors: Mahesh Chaubal, Mark J. Doty, Yefim Gelman, Monte Wisler
  • Method for preparing submicron particles of antineoplastic agents
    Publication number: 20040245662
    Abstract: The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.
    Type: Application
    Filed: November 7, 2003
    Publication date: December 9, 2004
    Inventors: Mahesh Chaubal, Jane Werling, Barrett Rabinow