Patents by Inventor Mahesh Hublikar

Mahesh Hublikar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of etravirine
    Patent number: 8653266
    Abstract: A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: February 18, 2014
    Assignee: Mylan Laboratories Limited
    Inventors: Vinayak Gore, Choudhari Bharati, Mahesh Hublikar, Prakash Bansode, Sandip Sinore
  • PROCESS FOR THE PRODUCTION OF ETRAVIRINE
    Publication number: 20130116433
    Abstract: A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.
    Type: Application
    Filed: April 26, 2012
    Publication date: May 9, 2013
    Inventors: Vinayak Gore, Choudhari Bharati, Mahesh Hublikar, Prakash Bansode, Sandip Sinore
  • CRYSTALLINE FORM OF SUNITINIB AND PROCESSES FOR ITS PREPARATION
    Publication number: 20120029046
    Abstract: The present invention relates to a novel crystalline form of sunitinib free base designated form I and to processes for its preparation. The invention also relates to its use as an API and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising the novel crystalline form and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 2, 2012
    Applicant: Generics (UK) Limited
    Inventors: Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode
  • NOVEL POLYMORPHS OF SUNITINIB AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20110263670
    Abstract: The present invention relates to novel polymorphs of sunitinib free base designated form II and form III and to processes for their preparation. The invention also relates to their use as APIs and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising said novel polymorphs and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.
    Type: Application
    Filed: August 24, 2009
    Publication date: October 27, 2011
    Inventors: Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode
  • PROCESS FOR THE PREPARATION OF CRYSTALLINE FORMS OF SUNITINIB MALATE
    Publication number: 20110257237
    Abstract: The present invention, relates to novel processes for the preparation of sunitinib malate formula (I), pharmaceutical compositions comprising said polymorph and the use of the said pharmaceutical compositions in the treatment of various forms of cancer.
    Type: Application
    Filed: July 9, 2009
    Publication date: October 20, 2011
    Applicant: GENERICS [UK] LIMITED
    Inventors: Abhay Gaitonde, Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode, Sunanda Phadtare