Patents by Inventor Mahesh Ramaseshan

Mahesh Ramaseshan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists
    Patent number: 7452862
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: November 18, 2008
    Assignee: Tranzyme Pharma, Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vézina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gérald Villeneuve, Hamid Hoveyda, Sylvie Beaubien, Graeme L Fraser
  • Macrocyclic modulators of the ghrelin receptor
    Publication number: 20060025566
    Abstract: The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
    Type: Application
    Filed: June 10, 2005
    Publication date: February 2, 2006
    Inventors: Hamid Hoveyda, Mark Peterson, Graeme Fraser, Mahesh Ramaseshan
  • Spatially-defined macrocyclic compounds useful for drug discovery
    Publication number: 20050137127
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: August 2, 2004
    Publication date: June 23, 2005
    Applicant: TRANZYME PHARMA INC
    Inventors: Pierre Deslongchamps, Yves Dory, Mark Peterson, Kamel Benakli, Eric Marsault, Luc Ouellet, Mahesh Ramaseshan, Martin Vezina, Daniel Fortin, Ruoxi Lan, Shigui Li, Gerald Villeneuve, Hamid Hoveyda, Sylvie Beaubien
  • Spatially-defined macrocycles incorporating peptide bond surrogates
    Publication number: 20050119169
    Abstract: Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: August 2, 2004
    Publication date: June 2, 2005
    Applicant: TRANZYME PHARMA INC.
    Inventors: Pierre Deslongchamps, Yves Dory, Luc Ouellet, Gerald Villeneuve, Mahesh Ramaseshan, Daniel Fortin, Mark Peterson, Hamid Hoveyda, Sylvie Beaubien, Eric Marsault