Patents by Inventor Mahmoud Ghannoum

Mahmoud Ghannoum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200093811
    Abstract: A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.
    Type: Application
    Filed: September 30, 2019
    Publication date: March 26, 2020
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Publication number: 20190358149
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Application
    Filed: July 3, 2019
    Publication date: November 28, 2019
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Patent number: 10426761
    Abstract: A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: October 1, 2019
    Assignee: ARMS Pharmaceutical, LLC
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Patent number: 10398645
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: September 3, 2019
    Assignee: ARMS PHARMACEUTICAL, LLC
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Patent number: 9987316
    Abstract: A method for controlling detrimental oral organisms in various individuals includes administering a priobiotic composition that includes one or more species or strains of beneficial fungi and/or one or more compounds produced therefrom that control one or more species of detrimental oral bacteria and/or other organisms.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: June 5, 2018
    Assignee: Case Western Reserve University
    Inventors: Mahmoud A. Ghannoum, Pranab Mukherjee
  • Publication number: 20150306042
    Abstract: A method for treating a body surface with an active agent, includes: administering a composition in a therapeutically effective amount to a body surface, the composition forming a barrier coating on the body surface that is active to sustain contact with the body surface for a duration of at least about one hour. The composition meets the following requirements: about 0.0001%<C<about 0.4%, about 0.07%<H<about 70%, optionally an antimicrobial A, and a therapeutically effective amount of X; or 0%<C<about 0.4%, about 55%<H<about 70%, optionally an antimicrobial A, and a therapeutically effective amount of X. All percentages are by weight of the total composition and C is a carbohydrate gum; H is a humectant; and A is the active agent, the active agent being active to produce a therapeutic effect on the body.
    Type: Application
    Filed: January 3, 2014
    Publication date: October 29, 2015
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Patent number: 8992893
    Abstract: In an embodiment, the barrier-forming composition includes a carbohydrate gum, a humectant, and an antimicrobial agent. The composition furthermore meets the following requirements: about 0.01%?C?about 0.4%; about 4.5%?H?about 65%; and 0.050%<A; or about 0%?C?about 0.4%; about 55%?H?about 65%; and 0.050%<A. C is the carbohydrate gum; H is the humectant; and A is the antimicrobial agent. All percentages are by weight of the total composition. In an embodiment the barrier-forming composition has an Rf value in water of 0 to about 0.25.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: March 31, 2015
    Assignee: ARMS Pharmaceutical, LLC
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Publication number: 20150031729
    Abstract: A method for trapping and neutralizing or killing microorganisms on a surface includes: applying a low tack coating composition that comprises an antimicrobial agent onto an inanimate surface; in the coating, killing or neutralizing microorganisms encountered on the surface and encountered from the environment after the applying step is performed; forming a coating layer on the inanimate surface. The composition comprises a humectant and an antimicrobial, the antimicrobial including a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof. The coating layer has antimicrobial cidal or static activity for at least about one hour. A low-tack antimicrobial composition is also included.
    Type: Application
    Filed: October 13, 2014
    Publication date: January 29, 2015
    Applicant: ARMS PHARMACEUTICAL, LLC
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Publication number: 20140186318
    Abstract: A method for controlling detrimental oral organisms in various individuals includes administering a priobiotic composition that includes one or more species or strains of beneficial fungi and/or one or more compounds produced therefrom that control one or more species of detrimental oral bacteria and/or other organisms.
    Type: Application
    Filed: September 16, 2013
    Publication date: July 3, 2014
    Applicant: Case Western Reserve University
    Inventors: Mahmoud A. Ghannoum, Pranab Mukherjee
  • Publication number: 20140051732
    Abstract: A method for trapping and neutralizing or killing microorganisms on a surface includes: applying a low tack coating composition that comprises an antimicrobial agent onto an inanimate surface; in the coating, killing or neutralizing microorganisms encountered on the surface and encountered from the environment after the applying step is performed; forming a coating layer on the inanimate surface. The composition comprises a humectant and an antimicrobial, the antimicrobial including a monoquaternary ammonium compound or pharmaceutically acceptable salt thereof. The coating layer has antimicrobial cidal or static activity for at least about one hour. A low-tack antimicrobial composition is also included.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: ARM PHARMACEUTICAL LLC
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Publication number: 20140051731
    Abstract: A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: ARMS Pharmaceutical LLC
    Inventors: Afif Mahmoud Ghannoum, Brian Vincent Sokol
  • Publication number: 20140005236
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Patent number: 8535646
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: September 17, 2013
    Assignee: ARMS Pharmaceutical LLC
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Publication number: 20130039959
    Abstract: A method for blocking, neutralizing, or killing human immunodeficiency virus (HIV) beginning prior to or during a human encountering an HIV contaminated environment or item includes: identifying a contaminated environment or item that is known or expected to be contaminated with HIV; and administering an effective amount of a barrier-forming composition to an oral or pharyngeal mucosa of the human prior to or during the human encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the HIV from contacting the mucosa, and provides cidal or static activity against HIV. A method for preventing the transmission of HIV through oral sexual relations, and a sexually transmitted disease prophylactic device are also provided.
    Type: Application
    Filed: October 18, 2012
    Publication date: February 14, 2013
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Publication number: 20130028848
    Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.
    Type: Application
    Filed: April 17, 2012
    Publication date: January 31, 2013
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Publication number: 20120270909
    Abstract: In an embodiment, the barrier-forming composition includes a carbohydrate gum, a humectant, and an antimicrobial agent. The composition furthermore meets the following requirements: about 0.01%?C?about 0.4%; about 4.5%?H?about 65%; and 0.050%<A; or about 0%?C?about 0.4%; about 55%?H?about 65%; and 0.050%<A. C is the carbohydrate gum; H is the humectant; and A is the antimicrobial agent. All percentages are by weight of the total composition. In an embodiment the barrier-forming composition has an Rf value in water of 0 to about 0.25.
    Type: Application
    Filed: April 17, 2012
    Publication date: October 25, 2012
    Inventors: Brian Vincent Sokol, Afif Mahmoud Ghannoum
  • Publication number: 20120265121
    Abstract: A method is described for the photodynamic treatment of a fungal infection in a subject by administering a therapeutically effective amount of a phthalocyanine compound or a pharmaceutically acceptable salt thereof to the subject and activating the phthalocyanine compound with light. The method is useful for treating various dermatophyte infections such as onychomycosis, and in particular fungal infection by Candida and Trichophyton.
    Type: Application
    Filed: March 19, 2012
    Publication date: October 18, 2012
    Applicant: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Elma D. Baron, Kevin D. Cooper, Minh Lam, Pranab Mukherjee, Mahmoud A. Ghannoum, Nancy L. Oleinick
  • Publication number: 20080220103
    Abstract: Provided is a method of treating a fungal infection on an animal epidermis, nail or hair, or in an orifice of an animal. The method comprises contacting the fungus infection with a composition comprising an antifungal botanical.
    Type: Application
    Filed: March 13, 2008
    Publication date: September 11, 2008
    Inventors: Jay Birnbaum, Thomas Blake, Mahmoud Ghannoum, Steven Vallespir
  • Publication number: 20070092547
    Abstract: This present teaching describes how to treat substrates with novel compositions in order to limit fungi, dermatophytes, yeasts, and bacteria thereon.
    Type: Application
    Filed: October 2, 2006
    Publication date: April 26, 2007
    Inventors: Jay Birnbaum, Thomas Blake, Mahmoud Ghannoum, Steven Vallespir, Mark Antonacci, Michael Ryan