Abstract: Fusion protein nanodisk compositions and methods of treating a variety of disorders by administration of the fusion protein nanodisk compositions to a patient in need are disclosed. The fusion protein nanodisks provide for the combined delivery of two different apolipoproteins to a subject in need. Fusion protein nanodiscs may include a phospholipid bilayer encompassed by a fusion membrane scaffold protein. The fusion membrane scaffold protein may include two different amphipathic alpha-helical proteins, such as apolipoproteins. Methods for treating a disorder by administering a therapeutic amount of the fusion protein nanodisc described above are also disclosed.

Abstract: The invention provides compositions that contain pathogen-binding nanodiscs and methods of using such compositions to treat and prevent pathogen infections. The compositions include nanodiscs functionalized with receptors that bind a pathogen. Binding of a pathogen to the nanodiscs neutralizes the pathogen by interfering with one or more aspects of its reproductive cycle. The compositions and methods are useful for treating or preventing infections in the body and for disinfecting aqueous fluids that may contain pathogens.

Abstract: Described herein are methods and compositions relating to nanodiscs, e.g., phospholipid bilayers with a proteinaceous belt or border. Further provided herein are loopable membrane scaffold proteins, e.g., for forming nanodiscs.

Abstract: A structural lightweight concrete composition comprising cement, a fine aggregate such as sand, a natural coarse aggregates, such as limestone, scoria or perlite or mixtures thereof, a synthetic coarse aggregate comprising a polymeric material, such as polypropylene beads, an industrial waste byproduct in the form of fine particles, such as silica fume or heavy oil ash, a superplasticizer, such as a polycarboxylate ether and water demonstrating lower thermal conductivity and sufficient compressive strength. Concrete products made therefrom and methods for producing such products are also provided.

Abstract: A structural lightweight concrete composition comprising cement, a fine aggregate such as sand, a natural coarse aggregates, such as limestone, scoria or perlite or mixtures thereof, a synthetic coarse aggregate comprising a polymeric material, such as polypropylene beads, an industrial waste byproduct in the form of fine particles, such as silica fume or heavy oil ash, a superplasticizer, such as a polycarboxylate ether and water demonstrating lower thermal conductivity and sufficient compressive strength. Concrete products made therefrom and methods for producing such products are also provided.

Abstract: Described herein are methods and compositions relating to nanodiscs, e.g., phospholipid bilayers with a proteinaceous belt or border. Further provided herein are loopable membrane scaffold proteins, e.g., for forming nanodiscs.

Abstract: A structural lightweight concrete composition comprising cement, a fine aggregate such as sand, a natural coarse aggregates, such as limestone, scoria or perlite or mixtures thereof, a synthetic coarse aggregate comprising a polymeric material, such as polypropylene beads, an industrial waste byproduct in the form of fine particles, such as silica fume or heavy oil ash, a superplasticizer, such as a polycarboxylate ether and water demonstrating lower thermal conductivity and sufficient compressive strength. Concrete products made therefrom and methods for producing such products are also provided.