Patents by Inventor Mahmoud Reza Jaafari

Mahmoud Reza Jaafari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240082156
    Abstract: A method for producing liposomes entrapping Cyclosporine A (CsA). The method comprising preparing a suspension of CsA-free liposomes with a pH level of 7, preparing a mixture with a pH level of 7 by adding the suspension of CsA-free liposomes in the sucrose phosphate buffer to an ethanolic solution of CsA, and forming the liposomes entrapping CsA by incubating the mixture at a temperature level between 42° C. and 48° C. for a time duration between 55 and 65 minutes.
    Type: Application
    Filed: November 15, 2023
    Publication date: March 14, 2024
    Inventors: Mahmoud Reza Jaafari, Seyed Ali Nazeri, Seyed Mahdi Rezayat, Ali Reza Partoazar
  • Patent number: 10428111
    Abstract: A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: October 1, 2019
    Inventors: Mahmoud Reza Jaafari, Masoumeh Zahmatkeshan, Seyed Mahdi Rezayat Sorkhabadi
  • Patent number: 10123973
    Abstract: Disclosed is a liposomal composition for treatment of cancer, which includes at least one PEG-Phospholipid conjugated molecule, cholesterol, and at least one phospholipid.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: November 13, 2018
    Assignees: MASHHAD UNIVERSITY OF MEDICAL SCIENCE, TEHRAN UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Mahmoud Reza Jaafari, Fatemeh Gheybi, Seyed Mahdi Rezayat Sorkhabadi
  • Patent number: 9987375
    Abstract: Anionic liposomes and apolipoprotein B-100 targeted immunoliposomes as therapeutic agents for dyslipidemia and related diseases, and compositions and methods for preparing same.
    Type: Grant
    Filed: September 21, 2014
    Date of Patent: June 5, 2018
    Inventors: Amirhossein Sahebkar, Ali Badiee, Mahmoud Reza Jaafari
  • Publication number: 20170183380
    Abstract: A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.
    Type: Application
    Filed: July 28, 2016
    Publication date: June 29, 2017
    Inventors: Mahmoud Reza Jaafari, Masoumeh Zahmatkeshan, Seyed Mahdi Rezayat Sorkhabadi
  • Publication number: 20170172921
    Abstract: A method for preparing a liposome composition for delivering polyphenolic compounds to the target organs may include preparing a complex that contains at least one polyphenolic compound. Then, encapsulating the polyphenolic compound into a liposome composition by admixing the prepared complex with the liposome ingredients.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 22, 2017
    Inventors: Mahmoud Reza Jaafari, Fatemeh Gheybi, Seyed Mahdi Rezayat Sorkhabadi
  • Publication number: 20170027868
    Abstract: Disclosed herein is a liposomal composition for treatment of cancer including PEGylated liposomes loaded by an anticancer drug, where the PEGylated liposome is further targeted by an effective number of P15 peptides.
    Type: Application
    Filed: October 17, 2016
    Publication date: February 2, 2017
    Inventors: Mahmoud Reza Jaafari, Shahrzad Amiridarban, Ali Badiee
  • Publication number: 20160228365
    Abstract: Disclosed is a liposomal composition for treatment of cancer, which includes at least one PEG-Phospholipid conjugated molecule, cholesterol, and at least one phospholipid.
    Type: Application
    Filed: April 15, 2016
    Publication date: August 11, 2016
    Inventors: Mahmoud Reza Jaafari, Fatemeh Gheybi, Seyed Mahdi Rezayat Sorkhabadi
  • Publication number: 20160045614
    Abstract: A liposomal composition for treatment of cancer including a PEGylated liposome loaded by an anthracycline chemotherapeutic agent, wherein the PEGylated liposome is further targeted by an effective number of affibody molecules.
    Type: Application
    Filed: August 17, 2015
    Publication date: February 18, 2016
    Inventors: Mahmoud Reza Jaafari, Seyyed Mahdi Rezayat, Javad Akhtari
  • Publication number: 20150147383
    Abstract: Anionic liposomes and apolipoprotein B-100 targeted immunoliposomes as therapeutic agents for dyslipidemia and related diseases, and compositions and methods for preparing same.
    Type: Application
    Filed: September 21, 2014
    Publication date: May 28, 2015
    Inventors: Amirhossein Sahebkar, Ali Badiee, Mahmoud Reza Jaafari
  • Publication number: 20150147382
    Abstract: A topical liposomal composition of Amphotricin B (AmB) and method for preparing same, which can be used as a composition and method for preparing topical liposomal compositions of other hydrophobic drugs. The formulation using AmphotricinB can be used for treating fungal or protozoan infections. The composition is stable with no significant changes in the sizes and AmB content of liposomes after storing at 4° C. and room temperature (22° C.) for more than 20 months. In in vivo and in vitro testing, the compositions exhibit high efficacy in treating cutaneous leishmaniasis.
    Type: Application
    Filed: September 19, 2014
    Publication date: May 28, 2015
    Applicant: Exir Nano Sina Company
    Inventors: Mahmoud Reza Jaafari, Ali Khamesipour