Abstract: Methods and compositions are disclosed to quantitatively measure in vivo blood vessel diameter, blood velocity, and other flow dynamics. Such methods and compositions can optimize therapeutic interventions designed to prevent or reduce the risk of cardiovascular and blood disorders. In one aspect, the methods and apparatus involve calculating blood vessel characteristics from a two dimensional image of a blood vessel in the conjunctiva of a subject's eye. In another aspect, a series of temporal images of a blood vessel are obtained to determine blood flow properties. The apparatus can include, for example, a biomicroscope, an illuminating light source and a high speed camera to acquire the series of temporal images with the data then analyzed by a programmed processor.

Abstract: Methods and compositions are disclosed to quantitatively measure in vivo blood vessel diameter, blood velocity, and other flow dynamics. Such methods and compositions can optimize therapeutic interventions designed to prevent or reduce the risk of cardiovascular and blood disorders. In one aspect, the methods and apparatus involve calculating blood vessel characteristics from a two dimensional image of a blood vessel in the conjunctiva of a subject's eye. In another aspect, a series of temporal images of a blood vessel are obtained to determine blood flow properties. The apparatus can include, for example, a biomicroscope, an illuminating light source and a high speed camera to acquire the series of temporal images with the data then analyzed by a programmed processor.

Abstract: Methods and compositions are disclosed to quantitatively measure in vivo blood vessel diameter, blood velocity, and other flow dynamics. Such methods and compositions can optimize therapeutic interventions designed to prevent or reduce the risk of cardiovascular and blood disorders. In one aspect, the methods and apparatus involve calculating blood vessel characteristics from a two dimensional image of a blood vessel in the conjunctiva of a subject's eye. In another aspect, a series of temporal images of a blood vessel are obtained to determine blood flow properties. The apparatus can include, for example, a biomicroscope, an illuminating light source and a high speed camera to acquire the series of temporal images with the data then analyzed by a programmed processor.

Abstract: Methods and apparatus are disclosed for measuring and mapping oxygen tension in a tissue and, in particular, permit direct non-invasive measurement of retinal tissue oxygen tension. In one aspect, the invention is directed to methods for determining oxygen tension in a target tissue sensitized with an oxygen sensitive probe by imaging the target tissue. In one embodiment, the invention provides a noninvasive method for monitoring oxygen tension in a chorioretinal tissue sensitized with an oxygen sensitive probe. In another aspect, apparatus is disclosed that can determine oxygen tension in tissue by quantifying a signal emitted by an oxygen sensitive probe within the three-dimensional map of a tissue to determine oxygen tension and provide a three-dimensional map of oxygen tension variations.

Abstract: Methods and apparatus are disclosed for measuring and mapping oxygen tension in a tissue and, in particular, permit direct non-invasive measurement of retinal tissue oxygen tension. In one aspect, the invention is directed to methods for determining oxygen tension in a target tissue sensitized with an oxygen sensitive probe by imaging the target tissue. In one embodiment, the invention provides a noninvasive method for monitoring oxygen tension in a chorioretinal tissue sensitized with an oxygen sensitive probe. In another aspect, apparatus is disclosed that can determine oxygen tension in tissue by quantifying a signal emitted by an oxygen sensitive probe within the three-dimensional map of a tissue to determine oxygen tension and provide a three-dimensional map of oxygen tension variations.