Patents by Inventor Mai KAMIKAWA

Mai KAMIKAWA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing blood chimeric animal
    Patent number: 11432537
    Abstract: The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal at a high percentage is sustained for a long period of time. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified, The gene that acts on the hematopoietic system is, for example, Lnk gene, When a medium to large mammal is used as a recipient, the survival rate of hematopoietic cells originating in a heterologous animal is dramatically increased such that blood chimerism of 10% or more can be maintained even in a 16 month old animal.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 6, 2022
    Assignees: THE UNIVERSITY OF TOKYO, NATIONAL FEDERATION OF AGRICULTURAL COOPERTIVE ASSOCIATIONS
    Inventors: Kazuo Fukawa, Tetsuya Ito, Mai Kamikawa, Yutaka Sendai, Hiromitsu Nakauchi, Satoshi Yamazaki, Motoo Watanabe
  • METHOD FOR PRODUCING BLOOD CHIMERIC ANIMAL
    Publication number: 20180177164
    Abstract: The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal, such as a human, at a high percentage is sustained for a long period of time, even in cases where a medium to large domestic animal is used as a recipient. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified. The gene that acts on the hematopoietic system is, for example, Lnk gene.
    Type: Application
    Filed: June 20, 2016
    Publication date: June 28, 2018
    Applicants: National Federation of Agricultural Cooperative Associations, The University of Tokyo
    Inventors: Kazuo FUKAWA, Tetsuya ITO, Mai KAMIKAWA, Yutaka SENDAI, Hiromitsu NAKAUCHI, Satoshi YAMAZAKI, Motoo WATANABE