Patents by Inventor Mai Yamashiro

Mai Yamashiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11136375
    Abstract: The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: October 5, 2021
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiki Yamada, Tatsuya Kiyasu, Kazuyuki Tabata, Akihiro Kuzumaki, Mai Yamashiro
  • Publication number: 20210300996
    Abstract: The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.
    Type: Application
    Filed: April 16, 2021
    Publication date: September 30, 2021
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiki YAMADA, Tatsuya KIYASU, Kazuyuki TABATA, Akihiro KUZUMAKI, Mai YAMASHIRO
  • Publication number: 20170275351
    Abstract: The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.
    Type: Application
    Filed: May 8, 2017
    Publication date: September 28, 2017
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiki Yamada, Tatsuya Kiyasu, Kazuyuki Tabata, Akihiro Kuzumaki, Mai Yamashiro
  • Patent number: 9683027
    Abstract: The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: June 20, 2017
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshiki Yamada, Tatsuya Kiyasu, Kazuyuki Tabata, Akihiro Kuzumaki, Mai Yamashiro
  • Publication number: 20100291627
    Abstract: The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.
    Type: Application
    Filed: October 14, 2008
    Publication date: November 18, 2010
    Inventors: Yoshiki Yamada, Tatsuya Kiyasu, Kazuyuki Tabata, Akihiro Kuzumaki, Mai Yamashiro