Abstract: Devices and methods are provided for the detection of CSF in a biological sample.

Abstract: A vibro-acoustography imaging system that generates a map of the mechanical response of a target to an acoustic radiation force, usually in low kHz range by a confocal geometry. The system generates two focused sinusoidal beams to produce a stress field at the beat frequency, which is a function of vibration and acoustic emissions field in terms of mechanical properties. A highly sensitive hydrophone is then used for detection of the acoustic emissions field, the amplitude of which may be correlated to the mechanical properties of the target tissue.

Abstract: A method for imaging tissue is provided. The method includes illuminating a target tissue via a light-emitting diode. The method further includes acquiring a plurality of timed images of the target tissue including an excitation image corresponding to an excitation state of the light-emitting. Additionally, the method includes generating a relative lifetime map of the target tissue based on the plurality of timed images.

Abstract: A system for selective spectral illumination in an operating room includes a housing, at least one light source disposed within the housing, the at least one light source configured to emit electromagnetic radiation at a plurality of wavelengths, and a controller coupled to the at least one light source and configured to control the at least one light source to emit electromagnetic radiation at one or more of the plurality of wavelengths based on a status of operation of an optical imaging system in the operating room.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample. In certain embodiments the device is a lateral flow device comprising: a porous substrate; a sample addition zone disposed on or in said porous substrate; a detection zone disposed on or in said porous substrate where said detection zone comprises at least a first test line (T1) and a second test line (T2) each test line comprising binding moieties that bind a complex formed between beta-trace protein (betaTP) and an indicator attached to a betaTP binding molecule; wherein said porous substrate defines a flow path through which a sample applied to the sample addition zone flows under capillary action away from said sample addition zone into said detection zone.

Abstract: An imaging system and method is disclosed for intraoperative surgical margin assessment in between various tissues and cell groupings having differing physiologic processes. The system uses an array of LED's to pump a target anatomy with a short excitation pulse and measures the lifetime of fluorescence to generate contrast. A relative fluorescence lifetime map is generated corresponding to the measured lifetime to identify boundaries within varying cell groupings and tissues.

Abstract: Systems and methods for performing multi-frequency harmonic acoustography for target identification and border detection are described, where a focused confocal transducer having a piezoelectric element and a hydrophone positioned centrally in the piezoelectric element is used. The transducer emits ultrasonic waves toward a target of interest at first and second frequencies. The two waves interfere at a focal plane within the target to generate a third acoustic wave. The target absorbs energy and emits its own unique vibration at the difference frequency (?f) of the two waves as well as its harmonics. The unique vibration is recorded with a hydrophone, and mechanical properties of the target are ascertained through detection and analysis of the third acoustic wave using a mathematical model implemented by a signal processing circuit.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample. In certain embodiments the device is a lateral flow device comprising: a porous substrate; a sample addition zone disposed on or in said porous substrate; a detection zone disposed on or in said porous substrate where said detection zone comprises at least a first test line (T1) and a second test line (T2) each test line comprising binding moieties that bind a complex formed between beta-trace protein (betaTP) and an indicator attached to a betaTP binding molecule; wherein said porous substrate defines a flow path through which a sample applied to the sample addition zone flows under capillary action away from said sample addition zone into said detection zone.

Abstract: A vibro-acoustography imaging system that that generates a map of the mechanical response of a target to an acoustic radiation force, usually in low kHz range by a confocal geometry. The system generates two focused sinusoidal beams to produce a stress field at the beat frequency, which is a function of vibration and acoustic emissions field in terms of mechanical properties. A highly sensitive hydrophone is then used for detection of the acoustic emissions field, the amplitude of which may be correlated to the mechanical properties of the target tissue.

Abstract: A time-resolved fluorescence imaging (TRFI) system that images a target medium without lifetime fitting. Instead of extracting the lifetime precisely, the system images the fluorophore distribution to allow for a simple and accurate method to obtain the fluorescence image without lifetime-extraction for time-resolved fluorescence imaging. An illumination source circuit for TRFI is also disclosed that shapes the excitation pulse. In one embodiment, the illumination source comprises an LED and stub line configured for generating a linear decay profile.