Patents by Inventor Maike Zimmermann

Maike Zimmermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for cytotoxic chemotherapy-based predictive assays
    Patent number: 11474106
    Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: October 18, 2022
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Paul Henderson, George D. Cimino, Chong-Xian Pan, Ralph William de Vere White, Maike Zimmermann, Kenneth W. Turteltaub
  • Methods of improving cancer chemotherapy
    Patent number: 11426385
    Abstract: Provided are methods and compositions for prolonging survival and/or reducing or inhibiting tumor growth in a cancer subject receiving a regimen of one or more chemotherapeutic agents, an inhibitor of soluble epoxide hydrolase (sEHi) and a non-steroidal anti-inflammatory drug (NSAID) that inhibits one or more enzymes selected from the group consisting of cyclo-oxygenase (“COX”)-1, COX-2, and 5-lipoxygenase (“5-LOX”). The methods and compositions decrease toxicity and/or adverse side effects in subjects receiving a regimen of one or more chemotherapeutic agents.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: August 30, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, United States as represented by the Department of Veterans Affairs
    Inventors: Bruce D. Hammock, Sung Hee Hwang, Ralph W. de Vere White, Chong-xian Pan, Hongyong Zhang, Paul Henderson, Ai-Hong Ma, Maike Zimmermann, Fuli Wang
  • Cytotoxic Chemotherapy-Based Predictive Assays for Acute Myeloid Leukemia
    Publication number: 20200010910
    Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient or a sample from the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.
    Type: Application
    Filed: July 10, 2019
    Publication date: January 9, 2020
    Inventors: Paul Henderson, George D. Cimino, Maike Zimmermann, Michael A. Malfatti, Kenneth W. Turteltaub, Ralph W. De Vere White, Brian Jonas, Tiffany Scharadin, Chong-Xian Pan
  • METHODS, SYSTEMS AND KITS FOR CYTOTOXIC CHEMOTHERAPY-BASED PREDICTIVE ASSAYS
    Publication number: 20180209984
    Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 26, 2018
    Inventors: Paul Henderson, George D. Cimino, Chong-Xian Pan, Ralph William de Vere White, Maike Zimmermann, Kenneth W. Turteltaub