Abstract: The invention relates to an applicator device comprising an applicator tip and a container part, wherein the container part comprises: (i) a container comprising a container wall, a valve, and a plunger, wherein the container wall, the valve, and the plunger together define a storage volume for containing a liquid, wherein the plunger comprises a circumferential wall, sealingly contacting the container wall; and (ii) a plunger advance system functionally coupled to the plunger and configured to advance the plunger for reducing the storage volume for expelling at least part of the liquid via said valve to said tip, wherein the plunger advance system is arranged outside the storage volume; wherein (a) the valve comprises a first spring system comprising a first spring material comprising a stainless steel material comprising a molybdenum content selected in the range of 0.5-7 wt.

Abstract: The invention addresses the problem of correctly positioning a catheter and reducing radiation doses. It relates to an X-ray imaging system (1) for a robotic catheter, comprising said catheter (3), and a processing unit (5) for receiving X-ray images of a patient environment (15). By being adapted to receive one or more auxiliary information items and using said information for determining the catheter position, the processing unit does not entirely have to rely on a large number of scanned image data, thus helping to reduce radiation while correctly delivering the catheter position as a function of as few as a single image, preferably 2D, and said one auxiliary information items. Further, said processing unit allows for at least one of rendering an image and provide said image to a visualization device (21), and providing feedback, e.g. steering commands, to said robotic catheter.

Abstract: An applicator (1) for topical application of an acidic liquid (30) includes a container (3) containing the acidic liquid. The container has an opening (31) in fluid contact with a nib (2) for a controlled release of the acidic liquid, wherein the nib includes a plurality of fibers (20) and an adhesive material (21) adhering the fibers. A kit of parts (100) for topical application of an acidic liquid is also provided and includes (a) a liquid release unit (40) provided with a nib for a controlled release of the acidic liquid, and (b) a container unit (50) which includes a container configured to contain the acidic liquid. The container unit further includes a liquid release element for application of the acidic liquid to the nib, wherein the nib has a plurality of fibers and an adhesive material adhering the fibers.

Abstract: The invention provides a dermatological kit comprising a first container comprising a first composition and a second container comprising a second composition, different from the first composition, wherein the first composition comprises trichloroacetic acid and a hibiscus acid, wherein the second composition comprises a material of Mauritia flexuosa origin and a hibiscus acid, and wherein the second composition has a sun protection factor (SPF) of at least 15.

Abstract: The invention relates to a composition for the treatment of superficial lesions, in particular skin lesions, mucous membrane lesions and/or nail lesions, an applicator comprising such a composition and the use of such a composition. The composition comprises an effective amount of trichloroacetic acid, at least one thickener, and at a physiologically acceptable solvent. And is effective against a plethora of superficial lesions selected from the group consisting of viral warts, verrucae, water warts (molluscum contagiosum), corns and calluses, and skin hyperpigmentation: age spots, solar lentigo, senial lentigo, acne, keratosis pilaris, actinic keratosis, mouth ulcers (canker sores), cold sores, ingrown toenails, onychomycosis, eyelid xanthelasma.

Abstract: The invention provides a dermatological composition comprising materials of algae origin (e.g. Arthrospira platensis) and olive leaf origin, the composition at least comprising a polypeptide and hydroxytyrosol. The composition is for use in the treatment and/or prevention of a dermatological microbial infection, e.g. nail fungus, Athlete's foot, wound, chickenpox, acne. The invention also provides an applicator device comprising such composition. Further, the invention provides a method for preparing such dermatological composition. Especially, the composition at least comprises a polypeptide and hydroxytyrosol.

Abstract: The invention relates to location determination apparatus for determining a location of a first object (2) like a catheter within a second object (3) being, for example, the heart of a person. The first object comprises a first ultrasound unit, and a second ultrasound unit (5) is located outside the second object. A location determination unit determines the location of the first object within the second object based on ultrasound signals transmitted 5 between the first ultrasound unit and the second ultrasound unit. This allows determining the location of the first object within the second object reliably in a way which is an alternative to using a transmission of electrical signals for determining the location and which may lead to an improved accuracy of determining the location.

Abstract: The invention relates to an applicator device comprising an applicator tip and a container part, wherein the container part comprises: (i) a container comprising a container wall, a valve, and a plunger, wherein the container wall, the valve, and the plunger together define a storage volume for containing a liquid, wherein the plunger comprises a circumferential wall, sealingly contacting the container wall; and (ii) a plunger advance system functionally coupled to the plunger and configured to advance the plunger for reducing the storage volume for expelling at least part of the liquid via said valve to said tip, wherein the plunger advance system is arranged outside the storage volume; wherein (a) the valve comprises a first spring system comprising a first spring material comprising a stainless steel material comprising a molybdenum content selected in the range of 0.5-7 wt.

Abstract: The invention relates to a composition for the treatment of superficial lesions, in particular skin lesions, mucous membrane lesions and/or nail lesions, an applicator comprising such a composition and the use of such a composition. The composition comprises an effective amount of trichloroacetic acid, at least one thickener, and at a physiologically acceptable solvent. And is effective against a plethora of superficial lesions selected from the group consisting of viral warts, verrucae, water warts (molluscum contagiosum), corns and calluses, and skin hyperpigmentation: age spots, solar lentigo, senial lentigo, acne, keratosis pilaris, actinic keratosis, mouth ulcers (canker sores), cold sores, ingrown toenails, onychomycosis, eyelid xanthelasma.

Abstract: Applicator (1) for topical application of an acidic liquid (30), the applicator comprising a container (3) containing said acidic liquid, the container comprising an opening (31) in fluid contact with a nib (2) for a controlled release of the acidic liquid, wherein the nib comprises a plurality of fibers (20) and an adhesive material (21) adhering the fibers. A kit of parts (100) for topical application of an acidic liquid, the kit of parts comprising (a) a liquid release unit (40) comprising a nib for a controlled release of the acidic liquid, and (b) a container unit (50) comprising a container configured to contain the acidic liquid, wherein the container unit further comprises a liquid release element for application of the acidic liquid to the nib, wherein the nib comprises a plurality of fibers and an adhesive material adhering the fibers.

Abstract: The invention provides a dermatological kit comprising a first container comprising a first composition and a second container comprising a second composition, different from the first composition, wherein the first composition comprises trichloro-acetic acid and a hibiscus acid, wherein the second composition comprises a material of Mauritia flexuosa origin and a hibiscus acid, and wherein the second composition has a sun protection factor (SPF) of at least 15.

Abstract: The invention provides a spray applicator (1) for topical treatment, the spray applicator (1) comprising a container (2) comprising a treatment liquid (52) under pressure and a propellant (51), wherein the container (2) is in fluid connection with a spray valve system (4) for application of at least part of the treatment liquid (52) on a topical area, wherein the treatment liquid (52) comprises an acid, wherein the container (2) comprises a container wall (20) having a top layer (22) and a top layer coating (21) on said top layer (22), wherein the top layer (22) optionally comprises a metal and wherein the top layer coating (21) comprises a polymer and/or a resin.

Abstract: The invention provides a dermatological composition comprising materials of algae origin (e.g. Arthrospira platensis) and olive leaf origin, the composition at least comprising a polypeptide and hydroxytyrosol. The composition is for use in the treatment and/or prevention of a dermatological microbial infection, e.g. nail fungus, Athlete's foot, wound, chickenpox, acne. The invention also provides an applicator device comprising such composition. Further, the invention provides a method for preparing such dermatological composition. Especially, the composition at least comprises a polypetide and hydroxytyrosol.

Abstract: The invention addresses the problem of correctly positioning a catheter and reducing radiation doses. It relates to an X-ray imaging system (1) for a robotic catheter, comprising said catheter (3), and a processing unit (5) for receiving X-ray images of a patient environment (15). By being adapted to receive one or more auxiliary information items and using said information for determining the catheter position, the processing unit does not entirely have to rely on a large number of scanned image data, thus helping to reduce radiation while correctly delivering the catheter position as a function of as few as a single image, preferably 2D, and said one auxiliary information items. Further, said processing unit allows for at least one of rendering an image and provide said image to a visualization device (21), and providing feedback, e.g. steering commands, to said robotic catheter.

Abstract: The invention relates to location determination apparatus for determining a location of a first object (2) like a catheter within a second object (3) being, for example, the heart of a person. The first object comprises a first ultrasound unit, and a second ultrasound unit (5) is located outside the second object. A location determination unit determines the location of the first object within the second object based on ultra-sound signals transmitted 5 between the first ultrasound unit and the second ultrasound unit. This allows determining the location of the first object within the second object reliably in a way which is an alternative to using a transmission of electrical signals for determining the location and which may lead to an improved accuracy of determining the location.

Abstract: The invention relates to a composition for the treatment of superficial lesions, in particular skin lesions, mucous membrane lesions and/or nail lesions, an applicator comprising such a composition and the use of such a composition. The composition comprises an effective amount of trichloroacetic acid, at least one thickener, and at a physiologically acceptable solvent. And is effective against a plethora of superficial lesions selected from the group consisting of viral warts, verrucae, water warts (molluscum contagiosum), corns and calluses, and skin hyperpigmentation: age spots, solar lentigo, senial lentigo, acne, keratosis pilaris, actinic keratosis, mouth ulcers (canker sores), cold sores, ingrown toenails, onychomycosis, eyelid xanthelasma.