Patents by Inventor Maiko LOHEL
Maiko LOHEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11361411Abstract: The invention relates to a method of neighbor influence compensation between a plurality of objects in at least one digital image, wherein the at least one digital image contains image information about a plurality of objects. Each of the plurality of objects is configured to receive at least one molecule comprising genetic information, wherein the at least one molecule is configured to receive a fluorescent compound, and the at least one digital image is taken by an optical imaging system during emission of electromagnetic radiation of the fluorescent compounds received by the at least one molecules.Type: GrantFiled: September 15, 2017Date of Patent: June 14, 2022Assignee: Qiagen GmbHInventors: Maiko Lohel, Thorsten Zerfass
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Publication number: 20210390666Abstract: Method and system for compensating intensity biases in a plurality of digital images. Each digital image of the plurality of digital images contains a plurality of objects and each of the plurality of objects is configured to receive at least one molecule comprising genetic information, wherein the at least one molecule is configured to receive one of at least a first fluorescent compound and a second fluorescent compound. A first digital image of the plurality of digital images is taken by an optical imaging system during emission of electromagnetic radiation by the first fluorescent compound, and a second digital image of the plurality of digital images is taken by the optical imaging system during emission of electromagnetic radiation by the second fluorescent compound.Type: ApplicationFiled: March 29, 2021Publication date: December 16, 2021Applicant: QIAGEN GmbHInventors: Thorsten ZERFASS, Maiko LOHEL, Fernando Carrillo OESTERREICH
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Publication number: 20210374915Abstract: The invention relates to a method of neighbor influence compensation between a plurality of objects in at least one digital image, wherein the at least one digital image contains image information about a plurality of objects. Each of the plurality of objects is configured to receive at least one molecule comprising genetic information, wherein the at least one molecule is configured to receive a fluorescent compound, and the at least one digital image is taken by an optical imaging system during emission of electromagnetic radiation of the fluorescent compounds received by the at least one molecules.Type: ApplicationFiled: September 15, 2017Publication date: December 2, 2021Applicant: QIAGEN GmbHInventors: Maiko LOHEL, Thorsten ZERFASS
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Patent number: 10991107Abstract: The present invention relates to a method and a system for aligning at least one part of a second digital image with at least one part of a first digital image comprising: dividing the at least one part of the first digital image into a plurality of tiles t_fi; dividing the at least one part of the second digital image into a plurality of tiles t_si; creating a plurality of correlation images fci; determining the position of a global maximum correlation value p_?? for each of the plurality of correlation images fci_??; calculating a plurality of first offset vectors fov, the offset vector fov_?? representing the offset between the tile t_si?? and the corresponding tile t_fi??; and aligning the at least one part of the second digital image with the at least one part of the first digital image by applying the corresponding first offset vectors fov.Type: GrantFiled: December 9, 2016Date of Patent: April 27, 2021Assignee: QIAGEN GmbHInventors: Guido Schuster, Thorsten Zerfass, Thomas Unterer, Jan Hauth, Maiko Lohel
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Patent number: 10963992Abstract: Method and system for compensating intensity biases in a plurality of digital images. Each digital image of the plurality of digital images contains a plurality of objects and each of the plurality of objects is configured to receive at least one molecule comprising genetic information, wherein the at least one molecule is configured to receive one of at least a first fluorescent compound and a second fluorescent compound. A first digital image of the plurality of digital images is taken by an optical imaging system during emission of electromagnetic radiation by the first fluorescent compound, and a second digital image of the plurality of digital images is taken by the optical imaging system during emission of electromagnetic radiation by the second fluorescent compound.Type: GrantFiled: October 20, 2017Date of Patent: March 30, 2021Assignee: QIAGEN GmbHInventors: Thorsten Zerfass, Maiko Lohel, Fernando Carrillo Oesterreich
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Patent number: 10878562Abstract: The present invention relates to a method and a system for the overall brightness of at least one object in a digital image. In particular, the method for determining the overall brightness of at least one object in a digital image, the at least one object being configured to receive molecules comprising genetic information, the method comprising the steps of: generating an area A comprising k sample points, the k points being distributed in the area A according to a predetermined distribution; aligning the center position of the area A to the center position of the at least one object in the digital image; extracting the intensity value at each of the k sample points; and calculating the central tendency of the extracted intensity values at the respective k sample points.Type: GrantFiled: December 9, 2016Date of Patent: December 29, 2020Assignee: Qiagen GmgHInventors: Maiko Lohel, Björn Labitzke, Thorsten Zerfass
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Publication number: 20200273183Abstract: The present invention relates to a method and a system for aligning at least one part of a second digital image with at least one part of a first digital image comprising: dividing the at least one part of the first digital image into a plurality of tiles t_fi; dividing the at least one part of the second digital image into a plurality of tiles t_si; creating a plurality of correlation images fci; determining the position of a global maximum correlation value p_v? for each of the plurality of correlation images fci_v?; calculating a plurality of first offset vectors fov, the offset vector fov_v? representing the offset between the tile t_siv? and the corresponding tile t_fiv?; and aligning the at least one part of the second digital image with the at least one part of the first digital image by applying the corresponding first offset vectors fov.Type: ApplicationFiled: December 9, 2016Publication date: August 27, 2020Inventors: Guido SCHUSTER, Thorsten ZERFASS, Thomas UNTERER, Jan HAUTH, Maiko LOHEL
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Patent number: 10740883Abstract: System, method and computer program product for background compensation of a digital image containing at least one first object, the at least one first object having received at least one molecule comprising genetic information, and at least one second object, the at least one second object not having received a molecule comprising genetic information, the at least one molecule being configured to receive a fluorescent compound, the digital image being determined by an optical imaging system during emission of electromagnetic radiation by the fluorescent compound.Type: GrantFiled: December 9, 2016Date of Patent: August 11, 2020Assignee: QIAGEN GmbHInventors: Thorsten Zerfass, Björn Labitzke, Maiko Lohel
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Patent number: 10733707Abstract: The present invention relates to a method and a system for determining the positions of a plurality of objects in a digital image by discriminating true positive positions of the plurality of objects from false positive candidate positions of the plurality of objects. In particular, the invention relates to a method for determining the positions of a plurality of objects in a digital image by discriminating true positive positions of the plurality of objects from false positive candidate positions of the plurality of objects, the plurality of objects being configured to receive molecules comprising genetic information.Type: GrantFiled: December 9, 2016Date of Patent: August 4, 2020Assignee: QIAGEN GmbHInventors: Thomas Unterer, Guido Schuster, Maiko Lohel, Björn Labitzke, Thorsten Zerfass
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Publication number: 20200243160Abstract: A method for performing a normalization of intensity values obtained to perform sequencing analysis comprises the steps: receiving (110) a plurality of image data for a plurality of channels, each image data (11a-11d, 15a-15d) describes for the respective channel (a-d) an intensity distribution over all positions of an image of the a plurality of image data (11 a-11 d, 15a-15d); parametrization (120) of the intensity distribution over all positions for the plurality of channels (a-d) to obtain parametrized distributions for the plurality of channels (a-d); combining (130) the parametrized distributions for the plurality of channels (a-d) to obtain a common distribution for all of the plurality of channels (a-d); and determining (140) for each of the plurality of channels (a-d) a transfer function such that the respective transfer function for the respective channel (a-d) maps the corresponding intensity distribution to the common distribution.Type: ApplicationFiled: June 19, 2018Publication date: July 30, 2020Inventors: Fernando OESTERREICH CARRILLO, MAIKO LOHEL, THORSTEN ZERFASS
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Publication number: 20190259137Abstract: Method and system for compensating intensity biases in a plurality of digital images. Each digital image of the plurality of digital images contains a plurality of objects and each of the plurality of objects is configured to receive at least one molecule comprising genetic information, wherein the at least one molecule is configured to receive one of at least a first fluorescent compound and a second fluorescent compound. A first digital image of the plurality of digital images is taken by an optical imaging system during emission of electromagnetic radiation by the first fluorescent compound, and a second digital image of the plurality of digital images is taken by the optical imaging system during emission of electromagnetic radiation by the second fluorescent compound.Type: ApplicationFiled: October 20, 2017Publication date: August 22, 2019Applicant: QIAGEN GmbHInventors: Thorsten ZERFASS, Maiko LOHEL, Fernando Carrillo OESTERREICH
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Publication number: 20190012770Abstract: The present invention relates to a method and a system for determining the positions of a plurality of objects in a digital image by discriminating true positive positions of the plurality of objects from false positive candidate positions of the plurality of objects. In particular, the invention relates to a method for determining the positions of a plurality of objects in a digital image by discriminating true positive positions of the plurality of objects from false positive candidate positions of the plurality of objects, the plurality of objects being configured to receive molecules comprising genetic information.Type: ApplicationFiled: December 9, 2016Publication date: January 10, 2019Inventors: Thomas UNTERER, Guido SCHUSTER, Maiko LOHEL, Björn LABITZKE, Thorsten ZERFASS
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Publication number: 20190012785Abstract: The present invention relates to a method and a system for the overall brightness of at least one object in a digital image. In particular, the method for determining the overall brightness of at least one object in a digital image, the at least one object being configured to receive molecules comprising genetic information, the method comprising the steps of: generating an area A comprising k sample points, the k points being distributed in the area A according to a predetermined distribution; aligning the center position of the area A to the center position of the at least one object in the digital image; extracting the intensity value at each of the k sample points; and calculating the central tendency of the extracted intensity values at the respective k sample points.Type: ApplicationFiled: December 9, 2016Publication date: January 10, 2019Inventors: Maiko LOHEL, Björn LABITZKE, Thorsten ZERFASS
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Publication number: 20190012773Abstract: System, method and computer program product for background compensation of a digital image containing at least one first object, the at least one first object having received at least one molecule comprising genetic information, and at least one second object, the at least one second object not having received a molecule comprising genetic information, the at least one molecule being configured to receive a fluorescent compound, the digital image being determined by an optical imaging system during emission of electromagnetic radiation by the fluorescent compound.Type: ApplicationFiled: December 9, 2016Publication date: January 10, 2019Inventors: Thorsten ZERFASS, Björn LABITZKE, Maiko LOHEL