Patents by Inventor Maiko Tanaka
Maiko Tanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200182850Abstract: The present invention provides a useful and efficient screening method for finding a cholinergic muscarinic M1 receptor positive allosteric modulator (M1PAM) with reduced cholinergic side effects. The present invention also provides a method for treating Alzheimer's disease and the like, a method for reducing cholinergic side effects, and the like which use M1PAM selected by the screening method and having a low ? value, or the M1PAM and an acetylcholinesterase inhibitor.Type: ApplicationFiled: May 17, 2018Publication date: June 11, 2020Inventors: Haruhide KIMURA, Yuu SAKO, Satoru MATSUDA, Yuji SHIMIZU, Emi KURIMOTO, Takao MANDAI, Maiko TANAKA
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Patent number: 10626405Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.Type: GrantFiled: July 15, 2016Date of Patent: April 21, 2020Assignee: Honda Motor Co., Ltd.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka, Masayuki Machida, Hiroko Hagiwara, Hideaki Koike, Mahoko Kuninaga
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Patent number: 10563209Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.Type: GrantFiled: July 15, 2016Date of Patent: February 18, 2020Assignee: Honda Motor Co., Ltd.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka, Masayuki Machida, Hiroko Hagiwara, Hideaki Koike, Mahoko Kuninaga
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Patent number: 10266833Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.Type: GrantFiled: July 15, 2016Date of Patent: April 23, 2019Assignee: Honda Motor Co., Ltd.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka, Masayuki Machida, Hiroko Hagiwara, Hideaki Koike, Mahoko Kuninaga
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Publication number: 20180208934Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.Type: ApplicationFiled: July 15, 2016Publication date: July 26, 2018Inventors: Satoru SHINKAWA, Shigenobu MITSUZAWA, Maiko TANAKA, Masayuki MACHIDA, Hiroko HAGIWARA, Hideaki KOIKE, Mahoko KUNINAGA
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Publication number: 20180208936Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.Type: ApplicationFiled: July 15, 2016Publication date: July 26, 2018Inventors: Satoru SHINKAWA, Shigenobu MITSUZAWA, Maiko TANAKA, Masayuki MACHIDA, Hiroko HAGIWARA, Hideaki KOIKE, Mahoko KUNINAGA
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Publication number: 20180201942Abstract: To provide a base sequence for protein expression that can increase the yield of protein such as diastatic enzyme by further activating a promoter of a particular gene. A base sequence 1 for protein expression includes: a gene 3 encoding protein 2; a promoter 4 of the gene 3, the promoter being linked upstream of the gene 3; and a cis element 5 whose activity is improved by an artificial transcription factor 6, the cis element being linked further upstream of the promoter 4. The cis element 5 is represented by SEQ ID NO: 1.Type: ApplicationFiled: July 15, 2016Publication date: July 19, 2018Inventors: Satoru SHINKAWA, Shigenobu MITSUZAWA, Maiko TANAKA, Masayuki MACHIDA, Hiroko HAGIWARA, Hideaki KOIKE, Mahoko KUNINAGA
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Patent number: 9688974Abstract: An Aspergillus mutant strain characterized in that it is an auxotrophic mutant strain of Aspergillus oryzae strain AOK27L.Type: GrantFiled: January 20, 2015Date of Patent: June 27, 2017Assignee: HONDA MOTOR CO., LTD.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka
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Patent number: 9605249Abstract: An object of the invention is to provide cellobiohydrolase with high activity. The activity of cellobiohydrolase can be improved by substituting, with alanine, asparagine that is the amino acid at position 62 from the N-terminal of cellobiohydrolase shown in SEQ ID NO: 1, or asparagine at a position corresponding to the position 62 in an amino acid sequence corresponding to the sequence of the cellobiohydrolase shown in SEQ ID NO: 1.Type: GrantFiled: December 3, 2015Date of Patent: March 28, 2017Assignee: HONDA MOTOR CO., LTD.Inventors: Shigenobu Mitsuzawa, Keiichi Kimura, Maiko Tanaka, Satoru Shinkawa
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Patent number: 9567563Abstract: Provided are an Aspergillus mutant strain which can dramatically enhance production of a heterologous enzyme when a saccharifying enzyme gene is transferred into the strain to perform transformation and a transformant having a saccharifying enzyme gene transferred into the Aspergillus mutant strain. The Aspergillus mutant strain has been completely or partially deficient in three genes of Aspergillus oryzae strain HO2 (accession number: NITE BP-01750): a prtR gene coding for a transcription factor; a pepA gene coding for an extracellular acid protease; and a cpI gene coding for an extracellular acid carboxypeptidase.Type: GrantFiled: February 3, 2016Date of Patent: February 14, 2017Assignee: HONDA MOTOR CO., LTD.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka, Tomohiro Imai
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Publication number: 20160230140Abstract: Provided are an Aspergillus mutant strain which can dramatically enhance production of a heterologous enzyme when a saccharifying enzyme gene is transferred into the strain to perform transformation and a transformant having a saccharifying enzyme gene transferred into the Aspergillus mutant strain. The Aspergillus mutant strain has been completely or partially deficient in three genes of Aspergillus oryzae strain HO2 (accession number: NITE BP-01750): a prtR gene coding for a transcription factor; a pepA gene coding for an extracellular acid protease; and a cpI gene coding for an extracellular acid carboxypeptidase.Type: ApplicationFiled: February 3, 2016Publication date: August 11, 2016Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka, Tomohiro Imai
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Publication number: 20160160200Abstract: An object of the invention is to provide cellobiohydrolase with high activity. The activity of cellobiohydrolase can be improved by substituting, with alanine, asparagine that is the amino acid at position 62 from the N-terminal of cellobiohydrolase shown in SEQ ID NO: 1, or asparagine at a position corresponding to the position 62 in an amino acid sequence corresponding to the sequence of the cellobiohydrolase shown in SEQ ID NO: 1.Type: ApplicationFiled: December 3, 2015Publication date: June 9, 2016Inventors: Shigenobu Mitsuzawa, Keiichi Kimura, Maiko Tanaka, Satoru Shinkawa
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Patent number: 9353364Abstract: The present invention relates to a polypeptide which has ?-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by SEQ ID NO: 1, or a polypeptide including an amino acid sequence having 91% or greater sequence identity with the amino acid sequence represented by SEQ ID NO: 1. According to the present invention, a novel ?-glucosidase enzyme derived from Acremonium cellulolyticus, a polynucleotide encoding the ?-glucosidase, an expression vector for expressing the ?-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the ?-glucosidase can be provided.Type: GrantFiled: July 7, 2014Date of Patent: May 31, 2016Assignee: Honda Motor Co., Ltd.Inventors: Maiko Tanaka, Shigenobu Mitsuzawa, Satoru Shinkawa, Daisuke Shibata, Takeshi Ara, Migiwa Takeda
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Patent number: 9228181Abstract: The present invention relates to a polypeptide which has ?-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by SEQ ID NO: 1, or a polypeptide including an amino acid sequence having 90% or greater sequence identity with the amino acid sequence represented by SEQ ID NO: 1. According to the present invention, a novel ?-glucosidase enzyme derived from Acremonium cellulolyticus, a polynucleotide encoding the ?-glucosidase, an expression vector for expressing the ?-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the ?-glucosidase can be provided.Type: GrantFiled: July 3, 2014Date of Patent: January 5, 2016Assignee: Honda Motor Co., Ltd.Inventors: Maiko Tanaka, Shigenobu Mitsuzawa, Satoru Shinkawa, Daisuke Shibata, Takeshi Ara, Migiwa Takeda
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Patent number: 9212368Abstract: An Aspergillus mutant strain obtained by deleting a ligD gene from an auxotrophic mutant strain of Aspergillus oryzae strain AOK27L.Type: GrantFiled: January 20, 2015Date of Patent: December 15, 2015Assignee: HONDA MOTOR CO., LTD.Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka
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Publication number: 20150203855Abstract: An Aspergillus mutant strain obtained by deleting a ligD gene from an auxotrophic mutant strain of Aspergillus oryzae strain AOK27L.Type: ApplicationFiled: January 20, 2015Publication date: July 23, 2015Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka
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Publication number: 20150203832Abstract: An Aspergillus mutant strain characterized in that it is an auxotrophic mutant strain of Aspergillus oryzae strain AOK27L.Type: ApplicationFiled: January 20, 2015Publication date: July 23, 2015Inventors: Satoru Shinkawa, Shigenobu Mitsuzawa, Maiko Tanaka
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Publication number: 20150017691Abstract: The present invention relates to a polypeptide which has ?-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by SEQ ID NO: 1, or a polypeptide including an amino acid sequence having 92% or greater sequence identity with the amino acid sequence represented by SEQ ID NO: 1. According to the present invention, a novel ?-glucosidase enzyme derived from Acremonium cellulolyticus, a polynucleotide encoding the ?-glucosidase, an expression vector for expressing the ?-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the ?-glucosidase can be provided.Type: ApplicationFiled: July 7, 2014Publication date: January 15, 2015Inventors: Maiko TANAKA, Shigenobu MITSUZAWA, Satoru SHINKAWA, Daisuke SHIBATA, Takeshi ARA, Migiwa TAKEDA
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Publication number: 20150017690Abstract: The present invention relates to a polypeptide which has ?-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by SEQ ID NO: 1, or a polypeptide including an amino acid sequence having 91% or greater sequence identity with the amino acid sequence represented by SEQ ID NO: 1. According to the present invention, a novel ?-glucosidase enzyme derived from Acremonium cellulolyticus, a polynucleotide encoding the ?-glucosidase, an expression vector for expressing the ?-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the ?-glucosidase can be provided.Type: ApplicationFiled: July 7, 2014Publication date: January 15, 2015Inventors: Maiko TANAKA, Shigenobu MITSUZAWA, Satoru SHINKAWA, Daisuke SHIBATA, Takeshi ARA, Migiwa TAKEDA
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Publication number: 20150017689Abstract: The present invention relates to a polypeptide which has ?-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by SEQ ID NO: 1, or a polypeptide including an amino acid sequence having 90% or greater sequence identity with the amino acid sequence represented by SEQ ID NO: 1. According to the present invention, a novel ?-glucosidase enzyme derived from Acremonium cellulolyticus, a polynucleotide encoding the ?-glucosidase, an expression vector for expressing the ?-glucosidase, a transformant incorporated with that expression vector, and a method for producing a cellulose degradation product using the ?-glucosidase can be provided.Type: ApplicationFiled: July 3, 2014Publication date: January 15, 2015Inventors: Maiko TANAKA, Shigenobu MITSUZAWA, Satoru SHINKAWA, Daisuke SHIBATA, Takeshi ARA, Migiwa TAKEDA