Patents by Inventor Maisam Dadgar
Maisam Dadgar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230271188Abstract: A cartridge for delivering a payload to cells of a cell suspension is provided, wherein the cartridge comprises an input channel that delivers the cell suspension to a first plurality of branch channels, and wherein the first plurality of branch channels each deliver the cell suspension into a respective one or a plurality of microfluidic chips or filters. Cell suspension exiting a microfluidic chip or filter flows into a respective one of a second plurality of branch channels, and is then delivered to an output channel by which it exits the cartridge. The cartridge may comprise a plurality of removable covers that hold the chips or filters in place against a body of the cartridge in which the input channel, output channel, and branch channels are formed.Type: ApplicationFiled: May 3, 2023Publication date: August 31, 2023Inventor: Maisam DADGAR
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Patent number: 11679388Abstract: A cartridge for delivering a payload to cells of a cell suspension is provided, wherein the cartridge comprises an input channel that delivers the cell suspension to a first plurality of branch channels, and wherein the first plurality of branch channels each deliver the cell suspension into a respective one or a plurality of microfluidic chips or filters. Cell suspension exiting a microfluidic chip or filter flows into a respective one of a second plurality of branch channels, and is then delivered to an output channel by which it exits the cartridge. The cartridge may comprise a plurality of removable covers that hold the chips or filters in place against a body of the cartridge in which the input channel, output channel, and branch channels are formed.Type: GrantFiled: April 6, 2020Date of Patent: June 20, 2023Assignee: SQZ Biotechnologies CompanyInventor: Maisam Dadgar
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Publication number: 20220241392Abstract: The present application provides formulations of modified peripheral blood mononuclear cells (PBMCs), wherein the formulation comprises: PBMCs comprising at least one antigen (e.g., a human papillomavirus (HPV) antigen) and a cryopreservation medium. In some embodiments, the PBMCs are conditioned by incubating the PBMC in the presence of an adjuvant.Type: ApplicationFiled: December 28, 2021Publication date: August 4, 2022Inventors: Howard BERNSTEIN, Scott LOUGHHEAD, Matthew BOOTY, Kelan HLAVATY, Tarek ABDELJAWAD, Maisam DADGAR, Jason MURRAY, David CHIRGWIN, Harry AN, Armon R. SHAREI
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Publication number: 20220233676Abstract: The present application provides formulations of activating antigen carriers (AACs), wherein the formulation comprises: AACs comprise at least one antigen and an adjuvant and a cryopreservation medium.Type: ApplicationFiled: December 28, 2021Publication date: July 28, 2022Inventors: Howard BERNSTEIN, Defne YARAR, Katarina BLAGOVIC, Amritha RAMAKRISHNAN, Maisam DADGAR, Louise CLEAR, Jason MURRAY, Tarek ABDELJAWAD, Claire PAGE
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Publication number: 20220203368Abstract: Provided is a microfluidic chip for causing the delivery of a payload to a cell comprising a first layer, a second layer, and a fluid flow region between the first layer and the second layer. This microfluidic chip is configured to accept flow of a cell suspension into the fluid flow region. The first layer of the microfluidic chip comprises a protrusion extending toward the second layer to form a constriction between the protrusion and the second layer, wherein the constriction is configured to cause perturbation of a cell membrane of a cell of the cell suspension as the cell passes through the constriction.Type: ApplicationFiled: December 27, 2021Publication date: June 30, 2022Inventor: Maisam DADGAR
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Publication number: 20220204902Abstract: A microfluidic chip for causing the delivery of a payload to a cell comprises a plurality of constrictions configured to allow a cell suspension to flow through one or more of the plurality of constrictions from a first fluid flow region to a second fluid flow region within the microfluidic chip, wherein a cross-sectional width of each of the plurality of constrictions is less than a diameter of cells in the cell suspension, such that membranes of the cells are perturbed when passing through the constrictions such that a payload is able to pass through the perturbed cell membranes, and wherein a quotient of a cross-sectional area over a cross-sectional perimeter of each of the plurality of constrictions is greater than greater than or equal to 0.5 ?m.Type: ApplicationFiled: December 27, 2021Publication date: June 30, 2022Inventors: Maisam DADGAR, Jacquelyn L. Sikora HANSON, Armon R. SHAREI
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Publication number: 20220071534Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: September 8, 2020Publication date: March 10, 2022Applicant: YourBio Health, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20210363479Abstract: The present disclosure generally relates to a systems and methods for processing cells, and kits for use with such methods and processes. In some aspects, the system, methods, and processes can be used to produce cell therapeutics.Type: ApplicationFiled: May 21, 2021Publication date: November 25, 2021Inventors: Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN
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Publication number: 20210228124Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: September 8, 2020Publication date: July 29, 2021Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20200332243Abstract: A system for delivering a payload to a cell that includes: a platform supporting an input container, an output container, and a receiver for receiving all or part of a disposable assembly, the disposable assembly including a preparation vessel and a constriction cartridge. The preparation vessel holds a cell suspension as it is prepared for passage through one or more cell-deforming constrictions, and the constriction cartridge houses a component that includes the one or more cell deforming constrictions. Passage through the cell-deforming constrictions causes perturbations in cell membranes to allow entry of a payload into the cells. The system includes one or more processors configured to receive input from a user and to automatically control pressure, temperature, agitation, and/or flow of the cell suspension as it passes through the input container, through the preparation vessel, through the constriction cartridge, and to the output container.Type: ApplicationFiled: December 18, 2018Publication date: October 22, 2020Inventors: Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN
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Patent number: 10799166Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: GrantFiled: June 27, 2017Date of Patent: October 13, 2020Assignee: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20200316604Abstract: A cartridge for delivering a payload to cells of a cell suspension is provided, wherein the cartridge comprises an input channel that delivers the cell suspension to a first plurality of branch channels, and wherein the first plurality of branch channels each deliver the cell suspension into a respective one or a plurality of microfluidic chips or filters. Cell suspension exiting a microfluidic chip or filter flows into a respective one of a second plurality of branch channels, and is then delivered to an output channel by which it exits the cartridge. The cartridge may comprise a plurality of removable covers that hold the chips or filters in place against a body of the cartridge in which the input channel, output channel, and branch channels are formed.Type: ApplicationFiled: April 6, 2020Publication date: October 8, 2020Inventor: Maisam DADGAR
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Publication number: 20180317829Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: June 27, 2017Publication date: November 8, 2018Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20180132774Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: June 27, 2017Publication date: May 17, 2018Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Patent number: 9730624Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: GrantFiled: July 11, 2014Date of Patent: August 15, 2017Assignee: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20150038876Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: July 11, 2014Publication date: February 5, 2015Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Patent number: 8827971Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: GrantFiled: April 26, 2012Date of Patent: September 9, 2014Assignee: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse
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Patent number: 8821412Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: GrantFiled: November 19, 2012Date of Patent: September 2, 2014Assignee: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
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Publication number: 20130138058Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: April 26, 2012Publication date: May 30, 2013Applicant: Seventh Sense Biosystems, Inc.Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse
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Publication number: 20130079666Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.Type: ApplicationFiled: November 19, 2012Publication date: March 28, 2013Applicant: SEVENTH SENSE BIOSYSTEMS, INC.Inventors: JAVIER GONZALEZ-ZUGASTI, A. DAVID BOCCUTI, DONALD E. CHICKERING, III, MARK MICHELMAN, RAMIN HAGHGOOIE, SHAWN DAVIS, SCOTT JAMES, MAISAM DADGAR, GREG FISHER, RICHARD L. MILLER, CHRISTOPHER J. MORSE, HOWARD BERNSTEIN, DOUGLAS A. LEVINSON