Patents by Inventor Majdi Najah

Majdi Najah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLUOROGENIC SUBSTRATES, METHODS OF MAKING THE SUBSTRATES, AND METHODS OF DETECTING GLYCOSIDASE ACTIVITIES
    Publication number: 20140234884
    Abstract: Fluorogenic substrates, methods of making the fluorogenic substrates, and methods of detecting glycosidase activities (EC3.2.1) are provided. The fluorogenic substrates are composed of a sugar covalently bonded to the 7-hydroxy position of a substituted coumarin sulfonated fluorophore is provided. The fluorogenic substrates include sodium ?-D-cellobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium ?-D-glucoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium ?-D-xyloside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium ?-D-xylobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; and sodium ?-D-xylopolyoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate. The fluorogenic substrates may be made by covalently bonding the sugar moiety to the 7-hydroxy position of the substituted coumarin sulfonated fluorophore by reaction in DMF.
    Type: Application
    Filed: March 14, 2014
    Publication date: August 21, 2014
    Applicants: UNIVERSITE DE STRASBOURG, ETS J. SOUFFLET
    Inventors: Antoine DREVELLE, Sylvain LADAME, Majdi NAJAH, Estelle MAYOT
  • Sulfonated coumarins, their synthesis, fluorogenic substrates resulting from grafting of these coumarins on sugars, method for obtaining these substrates, and their applications
    Patent number: 8716496
    Abstract: Substituted sulfonated coumarins are expressed in the general formula (I), where: R1 is H, OH, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R2 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R1 and R2 being capable of together forming a ring, such as a substituted or unsubstituted aryl or furane, R3 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, where R4 is H, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or a substituted or unsubstituted aryl, and M is Na or K.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: May 6, 2014
    Assignees: Universite de Strasbourg
    Inventors: Antoine Drevelle, Sylvain Ladame, Majdi Najah, Estelle Mayot
  • SULFONATED COUMARINS, SYNTHESIS THEREOF, FLUOROGENIC SUBSTRATES RESULTING FROM GRAFTING SAID COUMARINS ONTO SUGARS, METHOD FOR PREPARING SAID SUBSTRATES, AND USES THEREOF
    Publication number: 20130183700
    Abstract: Substituted sulfonated coumarins are expressed in the general formula (I), where: R1 is H, OH, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R2 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, R1 and R2 being capable of together forming a ring, such as a substituted or unsubstituted aryl or furane, R3 is H or a halogen, in particular fluorine, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or —COR4, or —COOR4, or —CONHR4, where R4 is H, or a substituted or unsubstituted, straight or branched C1-C6 alkyl radical, or a substituted or unsubstituted aryl, and M is Na or K.
    Type: Application
    Filed: September 16, 2011
    Publication date: July 18, 2013
    Applicants: UNIVERSITE DE STRASBOURG, ETS J. SOUFFLET
    Inventors: Antoine Drevelle, Sylvain Ladame, Majdi Najah, Estelle Mayot