Patents by Inventor Majed Matar

Majed Matar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID-LIPOPOLYMER COMPOSITIONS
    Publication number: 20180303957
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Application
    Filed: November 27, 2017
    Publication date: October 25, 2018
    Applicant: CLSN Laboratories, Inc.
    Inventors: Majed MATAR, Jason FEWELL, Danny H. LEWIS, Khursheed ANWER
  • Nucleic acid-lipopolymer compositions
    Patent number: 9827331
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: November 28, 2017
    Assignee: CLSN Laboratories, Inc.
    Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Immuno gene therapy for treatment of cancer and hyperproliferative diseases
    Patent number: 9468687
    Abstract: Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: October 18, 2016
    Assignee: CLSN LABORATORIES, INC.
    Inventors: Jason G. Fewell, Majed Matar, Jennifer Rice, Danny H. Lewis, Khursheed Anwer
  • NUCLEIC ACID-LIPOPOLYMER COMPOSITIONS
    Publication number: 20160243256
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 25, 2016
    Applicant: CLSN Laboratories, Inc.
    Inventors: Majed MATAR, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Polyamine derivatives
    Patent number: 9254334
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: February 9, 2016
    Assignee: CLSN Laboratories, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Nucleic acid-lipopolymer compositions
    Patent number: 9144546
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: September 29, 2015
    Assignee: CLSN Laboratories, Inc.
    Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Polyamine Derivatives
    Publication number: 20150099000
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 9, 2015
    Applicant: CLSN Laboratories, Inc.
    Inventors: Gregory SLOBODKIN, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Polyamine derivatives
    Patent number: 8932638
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: January 13, 2015
    Assignee: CLSN Laboratories, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Polyamine derivatives
    Patent number: 8900621
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 2, 2014
    Assignee: CLSN Laboratories, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Combination of Immuno Gene Therapy and Chemotherapy for Treatment of Cancer and Hyperproliferative Diseases
    Publication number: 20140186375
    Abstract: Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
    Type: Application
    Filed: January 6, 2014
    Publication date: July 3, 2014
    Applicant: EGEN, Inc.
    Inventors: Jason G. Fewell, Majed Matar, Jennifer Rice, Danny H. Lewis, Khursheed Anwer
  • Polyamine Derivatives
    Publication number: 20140050775
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 20, 2014
    Applicant: Egen, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
    Patent number: 8623837
    Abstract: Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: January 7, 2014
    Assignee: Egen, Inc.
    Inventors: Jason G. Fewell, Majed Matar, Jennifer Rice, Danny H. Lewis, Khursheed Anwer
  • Polyamine Derivatives
    Publication number: 20130251809
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 26, 2013
    Applicant: Egen, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Polyamine derivatives
    Patent number: 8460696
    Abstract: Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: June 11, 2013
    Assignee: Egen, Inc.
    Inventors: Gregory Slobodkin, Richard Congo, Majed Matar, Jason Fewell, Khursheed Anwer, Brian Jeffery Sparks
  • Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
    Patent number: 8445017
    Abstract: A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: May 21, 2013
    Assignee: Egen, Inc.
    Inventors: Gregory Slobodkin, Majed Matar, Jason Fewell, Khursheed Anwer
  • Nucleic Acid-Lipopolymer Compositions
    Publication number: 20130065942
    Abstract: Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 14, 2013
    Applicant: Egen, Inc.
    Inventors: Majed Matar, Jason Fewell, Danny H. Lewis, Khursheed Anwer
  • Biodegradable Cross-Linked Cationic Multi-block Copolymers for Gene Delivery and Methods of Making Thereof
    Publication number: 20120009145
    Abstract: A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
    Type: Application
    Filed: September 20, 2011
    Publication date: January 12, 2012
    Inventors: Gregory Slobodkin, Majed Matar, Jason Fewell, Khursheed Anwer
  • Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
    Patent number: 8057821
    Abstract: A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: November 15, 2011
    Assignee: EGEN, Inc.
    Inventors: Gregory Slobodkin, Majed Matar, Jason Fewell, Khursheed Anwer
  • Combination of Immuno Gene Therapy and Chemotherapy for Treatment of Cancer and Hyperproliferative Diseases
    Publication number: 20110218231
    Abstract: Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
    Type: Application
    Filed: May 17, 2011
    Publication date: September 8, 2011
    Inventors: Jason G. Fewell, Majed Matar, Jennifer Rice, Danny H. Lewis, Khursheed Anwer
  • Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
    Patent number: 7964571
    Abstract: Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: June 21, 2011
    Assignee: Egen, Inc.
    Inventors: Jason G. Fewell, Majed Matar, Jennifer Rice, Danny H. Lewis, Khursheed Anwer