Patents by Inventor Makan Khoshnejad

Makan Khoshnejad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA for In vivo Transfection with Increased Expression
    Publication number: 20250144234
    Abstract: This disclosure provides improved RNA molecules, including mRNA molecules that can be produced by in vitro transcription and are suitable for in vivo transfection using an appropriate delivery vehicle, such as a lipid nanoparticle (LNP) or targeted lipid nanoparticle (tLNP). The improved RNA include particular combinations of 5? untranslated region (UTR) and 3? UTR, particular 3? UTRs, or particular open reading frame sequences. Also provided herein are compositions of the LNP, or tLNP with an antibody as a targeting moiety, such as anti-CD8 antibodies that are used as targeting moiety.
    Type: Application
    Filed: November 1, 2024
    Publication date: May 8, 2025
    Inventors: Daiki Matsuda, Makan Khoshnejad, Yan Zhang, Duy Nguyen, Qian-Chen Yong, Haig Aghajanian, Adrian Ion Bot, Priya Prakash Karmali, Stuart Aaron Sievers
  • Nucleic acid monoclonal antibodies targeting PCSK9 and methods of use
    Patent number: 12110342
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 8, 2024
    Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: David Weiner, Makan Khoshnejad, Kar Muthumani, Ami Patel
  • NUCLEIC ACID MONOCLONAL ANTIBODIES TARGETING PCSK9 AND METHODS OF USE
    Publication number: 20200362055
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.
    Type: Application
    Filed: January 31, 2019
    Publication date: November 19, 2020
    Inventors: David Weiner, Makan Khoshnejad, Kar Muthumani, Ami Patel