Patents by Inventor Makarand Paranjape
Makarand Paranjape has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11534090Abstract: A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.Type: GrantFiled: October 20, 2017Date of Patent: December 27, 2022Assignee: Georgetown UniversityInventor: Makarand Paranjape
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Publication number: 20220113298Abstract: Systems and methods for characterizing cancer cells are disclosed. In certain embodiments, the systems and methods involve coating a first chamber with ECM material and adding a first plurality of cells to the first chamber, adding media to a second chamber, and adding a second plurality of cells and media to a third chamber. The first, second, and third chambers are then clipped together to form a chamber array. The chamber array is mounted to an electric cell impedance sensing reader and impedance readouts of cell invasion are collected from the electric array at time intervals. Cells detected to invade into the second chamber are extracted and characterized.Type: ApplicationFiled: September 9, 2019Publication date: April 14, 2022Inventors: Anton Wellstein, Ghada M. Sharif, Makarand Paranjape, Leon Der
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Publication number: 20220104732Abstract: A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.Type: ApplicationFiled: December 16, 2021Publication date: April 7, 2022Applicant: Georgetown UniversityInventors: Makarand Paranjape, Shruti M. Paranjape
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Patent number: 11247206Abstract: A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.Type: GrantFiled: January 31, 2018Date of Patent: February 15, 2022Assignee: Georgetown UniversityInventor: Makarand Paranjape
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Patent number: 11219390Abstract: A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.Type: GrantFiled: August 2, 2016Date of Patent: January 11, 2022Assignee: Georgetown UniversityInventors: Makarand Paranjape, Shruti M. Paranjape
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Publication number: 20200030796Abstract: A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.Type: ApplicationFiled: January 31, 2018Publication date: January 30, 2020Applicant: Georgetown UniversityInventor: Makarand Paranjape
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Publication number: 20190282149Abstract: A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.Type: ApplicationFiled: October 20, 2017Publication date: September 19, 2019Applicant: Georgetown UniversityInventor: Makarand Paranjape
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Publication number: 20180289299Abstract: A sensing device, designed to be used in contact with the skin, contains a plurality of individually controllable sites for electrochemically monitoring an analyte, such as glucose, in interstitial fluid of a user. The device includes at least a hydrophobic layer designed to contact the skin; a capillary channel providing an opening adjacent the skin; a metal electrode layer having a sensor layer applied to an edge portion thereof such that it is exposed to the interior of said capillary channel, the sensing layer being effective to measure the analyte.Type: ApplicationFiled: June 12, 2018Publication date: October 11, 2018Applicant: Georgetown UniverityInventor: Makarand Paranjape
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Patent number: 10004434Abstract: A sensing device, designed to be used in contact with the skin, contains a plurality of individually controllable sites for electrochemically monitoring an analyte, such as glucose, in interstitial fluid of a user. The device includes at least a hydrophobic layer designed to contact the skin; a capillary channel providing an opening adjacent the skin; a metal electrode layer having a sensor layer applied to an edge portion thereof such that it is exposed to the interior of said capillary channel, the sensing layer being effective to measure the analyte.Type: GrantFiled: March 15, 2013Date of Patent: June 26, 2018Assignee: Georgetown UniversityInventor: Makarand Paranjape
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Patent number: 9601697Abstract: A system for forming a functionalized sensor for sensing a molecule of interest includes at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for bioreceptors that react with the molecule of interest; and wherein applying a voltage to the third electrode causes the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.Type: GrantFiled: March 2, 2016Date of Patent: March 21, 2017Assignee: Georgetown UniversityInventors: Makarand Paranjape, Jianyun Zhou
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Publication number: 20170035331Abstract: A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.Type: ApplicationFiled: August 2, 2016Publication date: February 9, 2017Applicant: Georgetown UniversityInventors: Makarand Paranjape, Shruti M. Paranjape
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Patent number: 9431573Abstract: Devices incorporating a single to a few-layer MoS2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.Type: GrantFiled: June 4, 2014Date of Patent: August 30, 2016Assignee: Georgetown UniversityInventors: Makarand Paranjape, Paola Barbara, Amy Liu, Marcio Fontana
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Publication number: 20160181539Abstract: A system for forming a functionalized sensor for sensing a molecule of interest includes at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for bioreceptors that react with the molecule of interest; and wherein applying a voltage to the third electrode causes the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.Type: ApplicationFiled: March 2, 2016Publication date: June 23, 2016Applicant: Georgetown UniversityInventors: Makarand PARANJAPE, Jianyun ZHOU
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Patent number: 9332937Abstract: The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.Type: GrantFiled: September 25, 2013Date of Patent: May 10, 2016Assignees: Georgetown University, Leidos, Inc.Inventors: John F. Currie, Makarand Paranjape, Carl C. Peck, Robert White, Thomas W. Schneider
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Patent number: 9302908Abstract: A process for forming a functionalized sensor for sensing a molecule of interest includes providing at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith on a substrate; providing a third electrode including a decorating material on the substrate a predetermined distance from the at least one single or multi-wall carbon nanotube having a first and a second electrode in contact therewith, wherein the decorating material has a bonding affinity for a bioreceptors that react with the molecule of interest; and applying a voltage to the third electrode, causing the decorating material to form nanoparticles of the decorating material on the at least one single or multi-wall carbon nanotube.Type: GrantFiled: December 17, 2010Date of Patent: April 5, 2016Assignee: Georgetown UniversityInventors: Makarand Paranjape, Jianyun Zhou
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Publication number: 20150048387Abstract: Devices incorporating a single to a few-layer MoS2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.Type: ApplicationFiled: June 4, 2014Publication date: February 19, 2015Applicant: Georgetown UniversityInventors: Makarand PARANJAPE, Paola BARBARA, Amy LIU, Marcio FONTANA
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Patent number: 8895340Abstract: A process for forming a carbon nanotube field effect transistor (CNTFET) device includes site-specific nanoparticle deposition on a CNTFET that has one or more carbon nanotubes, a source electrode, a drain electrode, and a sacrificial electrode on a substrate with an interposed dielectric layer. The process includes control of PMMA removal and electrodeposition in order to select nanoparticle size and deposition location down to singular nanoparticle deposition. The CNTFET device resulting in ultra-sensitivity for various bio-sensing applications, including detection of glucose at hypoglycemic levels.Type: GrantFiled: September 10, 2013Date of Patent: November 25, 2014Assignee: Georgetown UniversityInventors: Makarand Paranjape, Yian Liu
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Publication number: 20140284631Abstract: Devices incorporating a single to a few-layer MoS2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.Type: ApplicationFiled: June 4, 2014Publication date: September 25, 2014Inventors: Makarand PARANJAPE, Paola BARBARA, Amy LIU, Marcio FONTANA
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Patent number: 8766330Abstract: Devices incorporating a single to a few-layer MoS2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.Type: GrantFiled: October 26, 2012Date of Patent: July 1, 2014Assignee: Georgetown UniversityInventors: Makarand Paranjape, Paola Barbara, Amy Liu, Marcio Fontana
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Publication number: 20140121485Abstract: A device contains individually controllable sites for electrochemically monitoring an analyte in interstitial fluid of a user. The sites include a conductive pattern attached at a first and second ends thereof to electrode material in a closed-circuit configuration for receiving a first predetermined voltage applied thereto in order to thermally ablate a stratum corneum of a user's skin to access the interstitial fluid and form an open-circuit configuration including first and second portions of the electrode material that are electrically isolated from each other; a sensing area deposited on at least one of the first and second portions of the electrode material; and a measuring component for receiving individual measurement data from the sensing area in response to a second predetermined voltage applied to the open circuit configuration. The individual measurement data is indicative of an amount of the analyte in the interstitial fluid.Type: ApplicationFiled: April 30, 2012Publication date: May 1, 2014Applicant: Georgetown UniversityInventors: Makarand Paranjape, Arend Jasper Nijdam, Yogesh Ekanath Kashte