Patents by Inventor Makato Kawai

Makato Kawai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1,4-dihydropyridine compounds as bradykinin antagonists
    Publication number: 20030176445
    Abstract: This invention provides a compound of the formula (I): 1
    Type: Application
    Filed: February 13, 2003
    Publication date: September 18, 2003
    Applicant: Pfizer Inc.
    Inventors: Yoshiyuki Okumura, Mitsuhiro Kawamura, Makato Kawai, Noriaki Murase, Takafumi Ikeda
  • 5-membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists
    Patent number: 6444677
    Abstract: This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein A is independently halo; Y1 is —(CH2)m—, C(O) or S(O); Y2 is N or CH; R1 and R2 are independently C1-4 alkyl; R3 is selected from the following: (a) optionally substituted —(CH2)p—C3-7 cycloalkyl; (b) optionally substituted —C5-7 alkyl; and (c) substituted —C1-4 alkyl; and (d) optionally substituted C7-9 bicycloalkyl; R4 is optionally substituted thiazolyl, imidazolyl or oxazolyl; X is S, —NH, —N—C1-4 alkyl or O; R5 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl or halo; m is 0, 1 or 2; n is 0, 1, 2, 3, 4 or S; and p is 0, 1, 2, 3, 4, 5 or 6. These compounds are useful for the treatment of medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: September 3, 2002
    Assignee: Pfizer Inc.
    Inventors: Takafumi Ikeda, Mitsuhiro Kawamura, Noriaki Murase, Seiji Nukui, Yuji Shishido, Makato Kawai, Yoshiyuki Okumura
  • Substituted 1,4-dihydropyridine compounds as bradykinin antagonists
    Publication number: 20020042421
    Abstract: This invention provides a compound of the formula (I): 1
    Type: Application
    Filed: September 27, 2001
    Publication date: April 11, 2002
    Inventors: Yoshiyuki Okumura, Mitsuhiro Kawamura, Makato Kawai, Noriaki Murase, Takafumi Ikeda
  • 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists
    Publication number: 20010046993
    Abstract: This invention provides a compound of the formula (I): 1
    Type: Application
    Filed: December 7, 2000
    Publication date: November 29, 2001
    Inventors: Takafumi Ikeda, Mitsuhiro Kawamura, Noriaki Murase, Seiji Nukui, Yuji Shishido, Makato Kawai, Yoshiyuki Okumura