Patents by Inventor Maki Iwahashi
Maki Iwahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9771357Abstract: The present invention provides a compound having ALXR agonist activity. Specifically, the invention provides a compound having ALXR agonist activity represented by general formula (I) wherein all the symbols are as defined in the specification, a salt thereof, a solvate thereof, or a prodrug thereof as well as an agent containing the same as an active ingredient for preventing and/or treating an ALXR-associated disease, such as an inflammatory bowel disease, an autoimmune disease, a chronic inflammatory disease, asthma, pulmonary fibrosis, atopic dermatitis, ischemia-reperfusion injury, myocardial infarction, or Alzheimer's disease.Type: GrantFiled: July 8, 2014Date of Patent: September 26, 2017Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Masahiko Terakado, Masaya Hirobe, Maki Iwahashi, Kousuke Tani, Tetsuya Sugiyama
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Publication number: 20160145249Abstract: The present invention provides a compound having ALXR agonist activity. Specifically, the invention provides a compound having ALXR agonist activity represented by general formula (I) wherein all the symbols are as defined in the specification, a salt thereof, a solvate thereof, or a prodrug thereof as well as an agent containing the same as an active ingredient for preventing and/or treating an ALXR-associated disease, such as an inflammatory bowel disease, an autoimmune disease, a chronic inflammatory disease, asthma, pulmonary fibrosis, atopic dermatitis, ischemia-reperfusion injury, myocardial infarction, or Alzheimer's disease.Type: ApplicationFiled: July 8, 2014Publication date: May 26, 2016Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Masahiko TERAKADO, Masaya HIROBE, Maki IWAHASHI, Kousuke TANI, Tetsuya SUGIYAMA
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Patent number: 9242977Abstract: An object of the present invention is to provide a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I): (wherein all symbols represent the same meanings as described in the specification), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.Type: GrantFiled: April 25, 2013Date of Patent: January 26, 2016Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Jun Takeuchi, Masahiro Ikura, Masato Higashino, Maki Iwahashi, Kazuya Hashimura
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Publication number: 20150111865Abstract: An object of the present invention is to provide a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I): (wherein all symbols represent the same meanings as described in the specification), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.Type: ApplicationFiled: April 25, 2013Publication date: April 23, 2015Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Jun Takeuchi, Masahiro Ikura, Masato Higashino, Maki Iwahashi, Kazuya Hashimura
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Patent number: 8138335Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.Type: GrantFiled: September 1, 2009Date of Patent: March 20, 2012Assignee: Ono Pharmaceutical Co., LtdInventors: Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, Seiji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
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Publication number: 20100029631Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.Type: ApplicationFiled: September 1, 2009Publication date: February 4, 2010Applicant: ONO Pharmaceutical Co., Ltd.Inventors: Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, Seiji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
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Patent number: 7601712Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.Type: GrantFiled: September 16, 2004Date of Patent: October 13, 2009Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, Seiji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
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Patent number: 7351705Abstract: A carboxylic acid compound represented by formula (I): (meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound.Type: GrantFiled: March 6, 2003Date of Patent: April 1, 2008Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Maki Iwahashi, Kaoru Kobayashi, Fumio Nambu
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Patent number: 7291644Abstract: Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.Type: GrantFiled: April 28, 2006Date of Patent: November 6, 2007Assignee: Ono Pharmaceuticals Co., Ltd.Inventors: Kazuhiko Torisu, Maki Iwahashi, Kaoru Kobayashi, Fumio Nambu
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Publication number: 20070004716Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.Type: ApplicationFiled: September 16, 2004Publication date: January 4, 2007Inventors: Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, SeijiKoji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
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Patent number: 7135495Abstract: Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification. and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.Type: GrantFiled: September 6, 2002Date of Patent: November 14, 2006Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kazuhiko Torisu, Maki Iwahashi, Kaoru Kobayashi, Fumio Nambu
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Publication number: 20060194864Abstract: Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification. and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.Type: ApplicationFiled: April 28, 2006Publication date: August 31, 2006Inventors: Kazuhiko Torisu, Maki Iwahashi, Kaoru Kobayashi, Fumio Nambu
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Publication number: 20060089353Abstract: An indole derivative compound represented by formula (I) (wherein the symbols in the formula are as mentioned in the specification) and a salt thereof Since the compounds represented by formula (I) binds to PGD2 receptors and shows antagonistic activity, they are believed to be useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, systemic mast cell activating disorder, anaphylaxis shock, airway contraction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis, urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleep disorder) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, autoimmune disease, chronic articular rheumatism, pleurType: ApplicationFiled: March 5, 2004Publication date: April 27, 2006Inventors: Maki Iwahashi, Atsushi Naganawa, Toshihiko Nishiyama, Toshihiko Nagase, Fumio Nambu
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Publication number: 20050222216Abstract: A carboxylic acid compound represented by formula (I): (meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound.Type: ApplicationFiled: March 6, 2003Publication date: October 6, 2005Inventors: Maki Iwahashi, Kaoru Kobayashi, Fumio Nambu
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Publication number: 20050004097Abstract: Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification. and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.Type: ApplicationFiled: September 6, 2002Publication date: January 6, 2005Inventors: Kazuhiko Torisu, Maki Iwahashi, Kaoru Kobayashi, Fumio Nambu