Patents by Inventor Maki KOTAKA

Maki KOTAKA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BILE DUCT CHIP AND USE THEREOF
    Publication number: 20240150691
    Abstract: There is provided a bile duct chip that is a bile duct chip (200) including a membrane (210) through which substances are movable from one surface to the other surface, a first substrate (221) having a recessed part that forms a first flow path (220), and a second substrate (231) having a recessed part that forms a second flow path (230), in which the first substrate (221), the membrane (210), the second substrate (231) are stacked in this order, the recessed part of the first substrate (221) has an opening portion facing the one surface of the membrane (210), the recessed part of the second substrate has an opening portion facing the other surface of the membrane (210), the one surface of the membrane (210) forms a part of the first flow path (220), the other surface of the membrane (210) forms a part of the second flow path (230), the first flow path (220) and the second flow path (230) communicate with each other through the membrane (210), and bile duct epithelial cells (222) are disposed on a surface of
    Type: Application
    Filed: March 9, 2022
    Publication date: May 9, 2024
    Inventors: Kazuo TAKAYAMA, Yusuke TORISAWA, Kenji OSAFUNE, Maki KOTAKA, Sayaka DEGUCHI, Hiroyuki MIZUGUCHI
  • Method for inducing hepatocytes
    Patent number: 10711249
    Abstract: A method for producing hepatocytes from hepatoblasts is provided. The method includes the step of culturing the hepatoblasts in a medium containing a compound selected from the group consisting of pregnenolone and an adrenergic agonist. The hepatoblasts can be obtained by culturing endodermal cells in a medium containing DMSO, and the endodermal cells can be obtained by culturing pluripotent stem cells in a medium containing Activin A and a GSK-3? inhibitor. Accordingly, a method for producing hepatocytes from pluripotent stem cells is also provided by employing the method of the present invention.
    Type: Grant
    Filed: December 25, 2015
    Date of Patent: July 14, 2020
    Assignee: KYOTO UNIVERSITY
    Inventors: Kenji Osafune, Maki Kotaka
  • HEPATOCYTE INDUCTION METHOD
    Publication number: 20180119095
    Abstract: A method for producing hepatocytes from hepatoblasts is provided. The method includes the step of culturing the hepatoblasts in a medium containing a compound selected from the group consisting of pregnenolone and an adrenergic agonist. The hepatoblasts can be obtained by culturing endodermal cells in a medium containing DMSO, and the endodermal cells can be obtained by culturing pluripotent stem cells in a medium containing Activin A and a GSK-3? inhibitor. Accordingly, a method for producing hepatocytes from pluripotent stem cells is also provided by employing the method of the present invention.
    Type: Application
    Filed: December 25, 2015
    Publication date: May 3, 2018
    Inventors: Kenji OSAFUNE, Maki KOTAKA