Patents by Inventor Maki Nishio

Maki Nishio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating fungal infections with serine analogs of BU-3608 antibiotics
    Patent number: 5183808
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: February 2, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics
    Patent number: 5114857
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: May 14, 1991
    Date of Patent: May 19, 1992
    Assignee: Bristol-Myers Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • Antifungal antibiotics
    Patent number: 5110960
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: May 5, 1992
    Assignee: Bristol-Myers Company
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • Process for producing antibiotics BU-3608 D and BU-3608 E
    Patent number: 5096817
    Abstract: Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: March 17, 1992
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Yosuke Sawada, Takeo Miyaki, Toshikazu Oki
  • Serine analogs of BU-3608 antibiotics
    Patent number: 5061624
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: October 29, 1991
    Assignee: Bristol-Myers Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • Pradimicin amide derivatives
    Patent number: 5053395
    Abstract: Disclosed herein are pradimicin amides which are active as antifungel agents.
    Type: Grant
    Filed: March 24, 1989
    Date of Patent: October 1, 1991
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Seiji Iimura, Toshikazu Oki
  • Antibiotics BU-3608D and BU-3608E
    Patent number: 4992425
    Abstract: Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
    Type: Grant
    Filed: June 7, 1988
    Date of Patent: February 12, 1991
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Yosuke Sawada, Takeo Miyaki, Toshikazu Oki
  • Antifungal antibiotics
    Patent number: 4990497
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: February 5, 1991
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • Serine analogs of BU-3608 antibiotics
    Patent number: 4973673
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: November 10, 1988
    Date of Patent: November 27, 1990
    Assignee: Bristol-Myers Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • BU-3608 derivatives
    Patent number: 4960755
    Abstract: Disclosed herein are N-alkyl derivatives of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: October 2, 1990
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Masatoshi Kakushima, Masataka Konishi, Toshikazu Oki
  • Polysubstituted thiazolylpyridine carboxyamide antifungal antibiotic
    Patent number: 4956374
    Abstract: Novel antifungal antibiotic compounds have the structural formula ##STR1## A preferred compound where R is 4-hydroxypentyl is denoted BU-3557B.sub.2. A complex of said compounds is produced by fermenting a culture of Sacchrothrix aerocolonigenes strain N806-4 (ATCC 53712). The complex is recovered by adsorption on nonionic porous polymer resin adsorbent and individual component compounds exhibit in vitro activity against fungi and Gram-positive bacteria and BU-3557B.sub.2 demonstrates in vitro antiprotazoal activity. BU-3557B.sub.2 demonstrates in vivo activity against C. albicans vaginal infection and BU-3557A.sub.3 (where R is 1,5-dihydroxy-5,5-dimethylpentyl) demonstrates in vivo activity against C. albicans systemic infection.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: September 11, 1990
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Shigeyuki Ando, Takeo Miyaki, Masataka Konishi, Toshikazu Oki
  • Antifungal antibiotics
    Patent number: 4870165
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: September 26, 1989
    Assignee: Bristol-Myers Company
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio