Patents by Inventor Maki UKAI

Maki UKAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene knockout method
    Patent number: 10863730
    Abstract: A method for producing a cell in which a target gene is knocked out, the method including the step of: introducing a CRISPR-Cas system into a cell having one or more kinds of target genes, the CRISPR-Cas system being able to produce (i) three or more kinds of guide RNAs for each of the one or more kinds of target genes and (ii) a Cas protein. The present invention can provide a method that enables highly efficient (90% or more) production of whole-body biallelic knockout animals in a single generation.
    Type: Grant
    Filed: December 25, 2015
    Date of Patent: December 15, 2020
    Assignee: RIKEN
    Inventors: Hiroki Ueda, Genshiro Sunagawa, Kenta Sumiyama, Maki Ukai, Dimitri Perrin
  • GENE KNOCKOUT METHOD
    Publication number: 20180020646
    Abstract: A method for producing a cell in which a target gene is knocked out, the method including the step of: introducing a CRISPR-Cas system into a cell having one or more kinds of target genes, the CRISPR-Cas system being able to produce (i) three or more kinds of guide RNAs for each of the one or more kinds of target genes and (ii) a Cas protein. The present invention can provide a method that enables highly efficient (90% or more) production of whole-body biallelic knockout animals in a single generation.
    Type: Application
    Filed: December 25, 2015
    Publication date: January 25, 2018
    Inventors: Hiroki UEDA, Genshiro SUNAGAWA, Kenta SUMIYAMA, Maki UKAI, Dimitri PERRIN